Example sentences for: cyclopamine

How can you use “cyclopamine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These results strongly support the model, initially hypothesized for cyclopamine [ 11 ] , that the reduced potency observed for Hh antagonists on Smo act-expressing cells is directly due to a reduced affinity of the antagonist for the mutated Smo protein.

  • Related results demonstrating the action of cyclopamine on Smo have been reported by Beachy and colleagues [ 51 52 ] .

  • It has been shown that the Hh-pathway antagonists cyclopamine and Cur61414 block signaling in a Ptc-independent manner [ 11 17 ] and therefore may act directly on Smo.

  • In contrast, the competition experiments with cyclopamine (Figure 4d) and Cur61414 (Figure 4e) showed that Hh protein and the agonist differ in their sensitivity to these antagonists.

  • Identical results were seen using the slightly less active cyclopamine-related natural compound jervine, and the more potent synthetic derivative of cyclopamine, KAAD-cyclopamine (data not shown).


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