Example sentences for: cyclopamine

How can you use “cyclopamine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These results strongly support the model, initially hypothesized for cyclopamine [ 11 ] , that the reduced potency observed for Hh antagonists on Smo act-expressing cells is directly due to a reduced affinity of the antagonist for the mutated Smo protein.

  • The Hh-blocking antibody 5E1 had no effect on pathway activation by the agonist (Figure 4b), while forskolin (Figure 4c), cyclopamine (Figure 4d) and Cur61414 (Figure 4e), were all inhibitory.

  • It has been shown that the Hh-pathway antagonists cyclopamine and Cur61414 block signaling in a Ptc-independent manner [ 11 17 ] and therefore may act directly on Smo.

  • Specifically, the agonist appears somewhat resistant to the inhibitory effect of cyclopamine and Cur61414.

  • These results argue that the agonist activates the pathway downstream of the Hh-Ptc interaction while cyclopamine, Cur61414 and the agonist may act at a similar level in the Hh-signaling cascade.


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