Example sentences for: cyclopamine

How can you use “cyclopamine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Specifically, the agonist appears somewhat resistant to the inhibitory effect of cyclopamine and Cur61414.

  • It has been shown that the Hh-pathway antagonists cyclopamine and Cur61414 block signaling in a Ptc-independent manner [ 11 17 ] and therefore may act directly on Smo.

  • Related results demonstrating the action of cyclopamine on Smo have been reported by Beachy and colleagues [ 51 52 ] .

  • These results strongly support the model, initially hypothesized for cyclopamine [ 11 ] , that the reduced potency observed for Hh antagonists on Smo act-expressing cells is directly due to a reduced affinity of the antagonist for the mutated Smo protein.

  • These include: a Hh-protein-blocking antibody, 5E1 [ 23 ] ; a natural product derivative, cyclopamine [ 9 10 ] that has recently been shown to act downstream of Ptc, perhaps at the level of Smo [ 11 ] ; a recently identified synthetic small-molecule inhibitor, Cur61414, which has inhibitory properties similar to cyclopamine [ 17 ] ; and forskolin, an adenylate cyclase/protein kinase A activator that is thought to block Hh signaling by stimulating degradation of members of the Gli family of transcriptional activators [ 2 ] .


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