Words similar to cyclopamine

Example sentences for: cyclopamine

How can you use “cyclopamine” in a sentence? Here are some example sentences to help you improve your vocabulary:

These include: a Hh-protein-blocking antibody, 5E1 [ 23 ] ; a natural product derivative, cyclopamine [ 9 10 ] that has recently been shown to act downstream of Ptc, perhaps at the level of Smo [ 11 ] ; a recently identified synthetic small-molecule inhibitor, Cur61414, which has inhibitory properties similar to cyclopamine [ 17 ] ; and forskolin, an adenylate cyclase/protein kinase A activator that is thought to block Hh signaling by stimulating degradation of members of the Gli family of transcriptional activators [ 2 ] .
Related results demonstrating the action of cyclopamine on Smo have been reported by Beachy and colleagues [ 51 52 ] .
The Hh-blocking antibody 5E1 had no effect on pathway activation by the agonist (Figure 4b), while forskolin (Figure 4c), cyclopamine (Figure 4d) and Cur61414 (Figure 4e), were all inhibitory.
Specifically, the agonist appears somewhat resistant to the inhibitory effect of cyclopamine and Cur61414.
In contrast, the competition experiments with cyclopamine (Figure 4d) and Cur61414 (Figure 4e) showed that Hh protein and the agonist differ in their sensitivity to these antagonists.