Example sentences for: conformational

How can you use “conformational” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Upon ligand binding, the SHR undergoes conformational changes that involve releas e from the repressor proteins, and translocation to the nucleus where it can bind to specific hormone responsive sequences in the DNA of genes regulated by steroid hormones [ 1 2 ] . The mechanism by which SHRs affect the rate of RNA polymerase II-directed transcription likely involves the interaction of receptors with components of the transcription preinitialization complex.

  • A second enzyme conformational change positions the cleaved DNA ends for religation (step 4).

  • This interaction unclasps the complex between the cytoplasmic tails, which then allows a conformational shift in the extracellular domain from a bent to a more extended form for high-affinity ligand binding (Figure 1) (Takagi et al.

  • The occupancy of CD4 and coreceptor binding sites by their respective ligands elicits downstream conformational changes in the envelope glycoprotein gp41, rendering it competent for fusion between virus and target cell membranes [ 18 19 40 41 42 43 ] . Shedding of gp120 from virus particles is not required for subsequent membrane fusion events [ 44 ] . The induction of gp41 six-helix bundles, detectable by mAb NC-1, by CAP in the absence of gp120 shedding is consistent with this conclusion.

  • Until this problem can be addressed at a fundamental theoretical level, it would seem prudent to employ an "energy-free" conformational search protocol.


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