Example sentences for: conformational

How can you use “conformational” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In summary, the results presented here suggest that treatment of HIV-1 with CAP leads to conformational changes in the envelope glycoproteins, ultimately resulting, in the absence of target cell membranes, in the formation of gp41 six-helix bundles.

  • Since the RING finger is a protein-protein interaction domain, interaction of the mammalian COP1 RING finger with another protein may, under certain conditions, trigger a conformational change of the surrounding peptides, altering the proximity between the two positive residue clusters of the NLS to disrupt binding to the nuclear import machinery.

  • For Taxol, application of commonly applied force fields as well as the semiempirical methods AM1 and PM3 results in an ordering of conformational energies that is method dependent and mostly inconsistent with experimental data.

  • Existing procedures for detection of point mutations include SSCP (single strand conformational polymorphism) [ 11 12 ] , a variation of SSCP called DOVAM (Detection of Virtually All Mutations) [ 19 ] , Enhanced SSCP [ 28 ] , HA (Heteroduplex Analysis) [ 13 14 ] , PTT (Protein Truncation Test) [ 15 ] , DGGE (Denaturing Gradient Gel Electrophoresis) [ 16 17 18 ] , chemical cleavage of mismatch [ 20 ] , and RNase cleavage [ 21 ] . Each of these procedures has its advantages and limitations but the size of the gene and the cost of the procedures have not made them routine in most laboratories.

  • The PEDF-heparin/HS complex may somehow facilitate encounters between PEDF and its receptor, e.g. , by inducing a conformational change in PEDF, which might accelerate the ligand-receptor interactions.


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