Words similar to conformational
Example sentences for: conformational
How can you use “conformational” in a sentence? Here are some example sentences to help you improve your vocabulary:
Less is known about the effects of carbenoxolone on GJs, although it has been proposed that glycyrrhetinic acid, to which carbenoxolone is related, binds directly to connexin molecules causing a conformational change leading to a closure of the junction [ 7 ] . Modeling studies indicate that neuronal synchronization can be mediated by low densities of GJs either between dendrites, as long as these dendrites are excitable [ 10 ] , or between the axons of pyramidal cells [ 11 ] . Furthermore, the electrotonic coupling could be promoted during epileptogenesis [ 12 13 ] .
Binding of GPIa/IIa to collagen induces a conformational change in receptor structure that enhances affinity.
The residues in the MIDAS motifs lie on three closely apposed loops located on the upper edge of the β-sheet, where they form the metal-binding site, with oxygen atoms in the aspartate, serine and threonine residues coordinating the metal ion [ 9 ] . In integrin α2β1, which is a collagen receptor, the metal-binding site also binds the collagen ligand through the conserved glutamate in a GFOGER motif (O = hydroxyproline) completing the coordination sphere of the metal [ 28 ] . In vivo, the binding of collagen at this site appears to be regulated through a conformational shift in which the loops forming the MIDAS site change from a closed to an open conformation [ 29 30 31 ] . Other proteins containing a domain with all three MIDAS motifs include the D-subunit of magnesium chelatase [ 32 ] , Ca-activated chloride-channel protein [ 33 34 ] , nitrate reductase (accession AAC79447), and the D subunit of nitric oxide reductase (accession AAC45374).
This could be ascribed to conformational changes in gp120, to the concealment of surface areas with the greatest negative charge on gp120 by CD4 [ 16 ] , (Fig.
Future work will be devoted to examining a range of functionalized organic molecules in order to define the boundary of molecular polarity within which standard conformational search methodology can be applied with confidence.
Loading...