Example sentences for: conformation

How can you use “conformation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This bias normally influences both the orientation and conformation of the ligand in the active site, which usually represents a local minimum conformation [ 14 ] . More importantly, the lock and key concepts used to evaluate enzyme-substrate binding, in reality, refer to flexible locks and keys that are both in constant dynamic (thermal) motion [ 15 ] . For example, an analysis of conformational changes upon complex formation for a representative set of 39 pairs of ligand-free and ligand-bound structures showed that 50% of these proteins undergo substantial main-chain and side chain conformational changes when the ligand is bound [ 15 ] .

  • This offset suggests that the NarL protein either occludes the minor groove of DNA, or that the DNA conformation is distorted upon NarL binding.

  • Both biophores #13 and #16 represent dopamine-like agonists that have restricted conformation for the sake of enhanced binding.

  • Apparently, other amino acids with small side chains can replace the glycines while maintaining the β-hairpin conformation of the phosphate-binding loop and avoiding steric interference with ATP binding.

  • Once free VO 2+occupies the catalytic site, the enzyme has to either release the metal or correct the conformation before the substrates are recruited properly.


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