Words similar to conformation
Example sentences for: conformation
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For example, Herschlag and co-workers have previously shown that a nucleobase could complement an abasic site within the hammerhead ribozyme, restoring cleavage activity [ 1 ] . Similarly, Porta and Lizardi engineered a hammerhead ribozyme that assumed an inactive secondary structure; upon the addition of an oligonucleotide that disrupted the engineered secondary structure, the ribozyme was activated [ 2 ] . More recently, it has previously been shown that many selected nucleic acid binding species (aptamers) undergo conformational changes upon ligand binding [ 3 4 5 6 ] In addition, when aptamers are conjoined to ribozymes, the ligand-induced conformational changes in the aptamers frequently modulate the structures and hence the activities of the ribozymes [ 7 8 9 ] For example, binding of theophylline to the anti-theophylline aptamer [ 10 ] modulates the conformation of residue [ 11 12 ] and the overall stability of the aptamer [ 10 13 ] . Appending the anti-theophylline aptamer to the hammerhead ribozyme allowed cleavage activity to be modulated by 110-fold by theophylline [ 13 ] . Similarly, appending the anti-theophylline aptamer to a small ribozyme ligase (L1) generated an aptazyme that was activated 1,600-fold by saturating theophylline concentrations [ 14 ] .
As we have reported that sCD39 releases intermediate ADP before ADP is further cleaved during ATP hydrolysis [ 25 ] , sCD39 probably has two conformations that bind metal-ADP complexes, one is the conformation that releases the ADP intermediate, and another that recruits intermediate ADP back to the enzyme for further hydrolysis to AMP.
Most of their data can be satisfied by a combination of two conformations by dramatically altering the position of M1 and the inner portion of M2 for the open conformation (personal observation).
[ 31 ] Hence, methods for predicting backbone conformation are not as developed as that for sidechains.
We have speculated that at 0.6 mg/ml DEAE dextran, hydrolysis of GTP may occur before the polymers are fully formed and rigidified, allowing the GDP-FtsZ to adopt the curved conformation.
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