Words similar to conformation
Example sentences for: conformation
How can you use “conformation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Chemokines are small, positively charged, secreted proteins that consist of an N-terminal region of variable conformation, three antiparallel beta-pleated sheets connected by loops, and a C-terminal alpha helix [ 1 ] . These proteins are multifunctional, with different regions of the molecules, in particular the N- and C-termini, performing specific functions [e.g.
Early models of Hh signaling proposed a Hh-regulated Ptc-Smo complex that directly controlled the conformation of Smo, making endogenous ligands unnecessary.
Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo; secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state; and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.
The first part of P dips into the transmembrane region as an α-helix and its latter portion returns to the surface in a relatively extended conformation that lies near the four-fold axis of the pore.
It is tempting to speculate that, under certain conditions, the mammalian COP1 NES is shielded within the coiled-coil structure and COP1 protein is imported into the nucleus through the RING finger bridged NLS; under other conditions, probably through a conformation change of the coiled-coil domain, the NES is exposed, overwriting the NLS and transporting mammalian COP1 back into the cytoplasm.
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