Words similar to cleaving
Example sentences for: cleaving
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Within the MMP family, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) are expressed in arthritic joints, and efficiently degrade type II collagen [ 9 ] . MMP-13 is more effective than MMP-1 in cleaving type II collagen, but it is debated which is the principal collagenase in vivo [ 10 11 ] . These enzymes have been implicated in the pathology of rheumatoid arthritis (RA) and osteoarthritis (OA), and have long been therapeutic targets [ 12 ] . Historically, inhibition of MMP-active sites has been a strategy; however, with wide-ranging side-effects and lack of efficacy, these studies are proving unfruitful in providing an effective drug [ 13 ] .
Indeed, the scholarly journals have been overflowing with turgid prose for decades, and it is particularly refreshing to know that comment on virtually any aspect of language can still be offered in language that, glowing with respectability, cleaving to the well-turned phrase, punctuated by the provocative pun, can be so engagingly presented.
From Jules and Jim there are the plucked, fragrant melodies that stop brilliantly short of cloying, the spasm of frantic neo-Baroque fiddling from Day for Night , and the tangy sounds of an out-of-tune barroom upright from Shoot the Piano Player . In these eclectic sketches--which capture an image but have no emotional arc of their own--the irony of this project comes into focus: the contradiction of championing film music by cleaving it from film.
Besides cleaving the phosphate backbone, to achieve specificity APEs must coordinate a series of functions, including: interaction with target DNA in a series of small, possibly repetitive steps (scanning), locating damage sites, establishing the transition state complex, completing the cleavage, re-adjusting the charge status within the active site, and regulating release of product after interaction with the next enzyme in the BER pathway [ 20 21 22 23 24 25 ] . A finer breakdown of these functions can be achieved at the molecular level once all the residues in the reaction mechanism are known.
The siRNAs are incorporated into a macromolecular complex which carries out degradation of homologous RNA sequences [ 14 ] . Dicer action serves to inhibit viral infection and retroposon movement, and also plays a role in developmental pathways by cleaving precursors to small regulatory RNAs (reviewed in [ 14 15 ] ). The predicted sequence of the mouse Dicer polypeptide exhibits a single dsRBM and tandem catalytic domains.
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