Example sentences for: cleaving

How can you use “cleaving” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cell division can then be thought of as a series of intermediate cell shapes (sphere, cylinder and dumbbell) that are produced along this pathway of cleaving the mother cell.

  • APEs are essential for mammalian cell growth and bacterial survival in the presence of ionizing radiation and DNA mutagens [ 6 ] . They initiate repair of an abasic DNA site by cleaving the phosphodiester backbone 5' of the phosphodeoxyribose.

  • PCR was used to amplify DNA coding for the FMDV/2A self cleaving protein The 5' primer was 5'CAGCTGTTGAATTTTGACCTTCTTAAGCTTGCGGGAGACGTCGAGTCCAACCCTGGCCCC3' and the 3' primer was 5'ATACAGCGTCACGACTCCCACCAATACTAGTGACACAGACAGTGAGGTGCTGGGGCCAGGGTTGGACTCGAC.

  • Within the MMP family, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) are expressed in arthritic joints, and efficiently degrade type II collagen [ 9 ] . MMP-13 is more effective than MMP-1 in cleaving type II collagen, but it is debated which is the principal collagenase in vivo [ 10 11 ] . These enzymes have been implicated in the pathology of rheumatoid arthritis (RA) and osteoarthritis (OA), and have long been therapeutic targets [ 12 ] . Historically, inhibition of MMP-active sites has been a strategy; however, with wide-ranging side-effects and lack of efficacy, these studies are proving unfruitful in providing an effective drug [ 13 ] .

  • Most of this shedding is catalyzed by the α-secretase pathway, but a trace amount (<5% [49]) is catalyzed by β-secretase/β-site APP cleaving enzyme [50].


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