Words similar to cleaves
Example sentences for: cleaves
How can you use “cleaves” in a sentence? Here are some example sentences to help you improve your vocabulary:
The commentariat cleaves roughly along ideological lines.
Fas contains a single transmembrane domain and belongs to the tumor necrosis factor (TNF)/nerve growth factor family [ 8 ] . FasL contains a single transmembrane domain and is also a member of the same TNF family [ 9 ] . A soluble form of FasL has been described, but appears to be less capable of inducing apoptosis, when compared with the bound form [ 10 11 ] . The binding of FasL with Fas initiates receptor oligomerization, which recruits Fas-associated death domain (FADD) [ 12 ] . FADD binds procaspase-8 and permits activation of caspase-8 through self-cleavage [ 13 ] . Caspase-8 activates the effector caspases, which commits the cell to the orderly process of apoptosis [ 14 15 ] . In addition, caspase-8 cleaves Bcl-2-interactive-death-agonist (Bid) [ 16 ] . Truncated Bid localizes to the mitochondria and promotes cytochrome c release; this process also serves as a major apoptotic-signaling pathway for Fas [ 16 17 18 ] . Depending upon the amount of caspase-8 that is activated, the predominant pathway can be either Bid cleavage with subsequent mitochondrial release of cytochrome c or activation of the effector caspase pathway [ 18 ] . Resident cells of the kidney express both Fas and FasL and Fas/FasL signaling is functional in these cells [ 19 20 21 22 23 24 ] . A recent review by Ortiz and associates [ 25 ] noted that the combined literature demonstrating participation of Fas/FasL pathway in renal injury essentially fulfilled Koch's postulates.
In this regard, the S. cerevisiae RNase III orthologue Rnt1p not only cleaves the 35 S rRNA precursor within the 3'-ETS [ 27 28 29 ] , but also processes snoRNA and snRNA precursors [ 30 31 32 33 ] . Further biochemical studies are required to identify the RNA targets for mammalian RNase III and to determine its involvement in RNA maturation pathways.
The endonuclease activity of DNase 1 is reduced many fold by integrating this loop from E. coli exonuclease III, but the mutant cleaves at abasic sites in DNA with low efficiency [ 29 ] . Thus additional residues in the APEs control specificity while still allowing a reasonable rate of phosphorolytic cleavage.
Previous studies have shown that E. coli DNA topoisomerase I cleavage of single-stranded DNA occurs with selectivity for sites with the C nucleotide base at the - 4 position [ 9 10 ] and that the enzyme preferentially cleaves at junctions of double-stranded and single-stranded DNA [ 8 ] . Several different 5'-end labeled substrates were prepared and used in cleavage assays to compare the cleavage sites selected by Top67 versus topoisomerase I. The results showed that with single-stranded substrates, Top67 also preferred cleavage sites with a C nucleotide base at the -4 position as reported for most of the type IA topoisomerases [ 12 ] . There were some differences from topoisomerase I in the relative distribution of cleavage products among the potential cleavage sites (Figure 4a,4b).
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