Words similar to cleft

Example sentences for: cleft

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The LBD utilizes a large hydrophobic cleft composed of residues along H3 and H5 to bind IDs [ 17 ] , and a smaller hydrophobic cleft that is composed of residues in the upper part of H3 and H5 and H12 (and corresponds to AF-2) to bind NR boxes [ 18 ] . Thus, agonists promote coregulator exchange by promoting the packing of H12 over the lower part of the ID binding region, an event that simultaneously completes the coactivator binding surface.
This observation, taken together with the spatial proximity of the two DPBBs in the catalytic cleft of the DDRP (Fig.
It is apparent, however, that [ 3H]granisetron does occupy the same binding cleft as other 5-HT 3 R ligands as evidenced by the ability of 5-HT, m CPBG, d -tc and lerisetron to displace it from the binding site.
The α subunit further stabilizes this cleft, whereas the ω subunit interacts with the β' subunit [ 7 ] . Given their ubiquitous presence in all cellular life forms and high level of sequence conservation, it seems evident that the core subunits of this complex RNA synthesis machine were already present in the last universal common ancestor (LUCA) of the extant cellular life forms and performed functions mechanistically similar to those of modern DDRP.
However, the DPBBs from the two DDRP subunits are spatially juxtaposed in the DDRP crystal, with the catalytic cleft located between them.