Words similar to cleft
Example sentences for: cleft
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Of these, four subunits, which correspond to the bacterial α, β, β' and ω, are universally present in all cellular DDRPs and constitute the conserved DDRP core [ 7 ] . Orthologs of the β and β' subunits are also encoded in the genomes of several families of large eukaryotic DNA viruses [ 33 34 35 ] . Biochemical studies have shown that the catalytic site of DDRP resides in the β' subunit and contains three invariant aspartates that coordinate a Mg 2+cation [ 22 23 24 36 ] . Recent structural analyses demonstrated that the core of DDRP is assembled around the β and β' subunits, which interact with each other to form a positively charged nucleic-acid-binding cleft.
These results suggest that the optimal size of the β7-β8 loop in the second subunit of the HIV-1 RT dimer is crucial for opening the polymerase cleft of the p66 subunit.
Significantly, among the five subtypes of muscarinic ACh receptors (MAChRs), Ml and M3 receptors have been shown to efficiently activate PLD (and PKC) in various cell types [ 26 27 28 29 30 ] , whereas activation of PLD by M2 and M4 receptors is less robust [ 26 ] . These observations suggest that in a cholinergic synapse, ACh released into the synaptic cleft might stimulate PLD activity leading to a release of choline that could be used for ACh synthesis.
The primary support for the pelvic organs comes from the pelvic floor muscles [ 1 2 ] . This suggests that an alteration to the levator ani supportive function may significantly contribute to the pathogenesis of PFD [ 3 ] , which affect 5% of younger and nearly 50% of elderly women [ 2 ] . In women, the levator muscles form a horizontal shelf with an anterior midline cleft (the urogenital hiatus) through which the urethra, vagina, and rectum pass.
"Pierced ears, cleft chins or dimples are not currently available."
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