Words similar to cleft
Example sentences for: cleft
How can you use “cleft” in a sentence? Here are some example sentences to help you improve your vocabulary:
Japanese tabi are white cotton socks with a practical cleft between big and second toe to go under thong sandals, but as a beige leather, high-heeled boot, the effect is that of a perfect cloven hoof.
Despite the fact that p51 shares an identical amino acid sequence with the N-terminal portion of p66, the two subunits assume different global folding patterns in the formation of the asymmetric heterodimer [ 9 ] . Structural determination through X-ray crystallography has revealed that the p66 subunit of HIV-1RT has its polymerase domain in an "open" conformation, with its subdomains forming a large cleft which accommodates DNA.
The conserved basic residue interacts with the carboxylate group of the acidic substrate, while the bulky or aromatic residue located carboxy-terminal to the basic one forms the base of the cleft that holds this substrate molecule (Figure 2).
Although the cores of the two DDRP subunits are homologous and are likely to have evolved from a common ancestor (see discussion below), they have completely different sets of conserved residues and contribute distinct moieties to the catalytic cleft (Figs.
The isolated E. coli RNase III catalytic domain, which retains homodimeric behavior, can cleave dsRNA substrates under specific conditions in vitro [ 11 ] . The recently reported crystal structure of the catalytic domain of Aquifex aeolicus RNase III reveals an extensive subunit interface, with the cleft between the subunits predicted to bind dsRNA [ 12 ] . The two proposed active sites are positioned at each end of the intersubunit cleft and contain conserved residues from each subunit.
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