Words similar to cleft
Example sentences for: cleft
How can you use “cleft” in a sentence? Here are some example sentences to help you improve your vocabulary:
Significantly, among the five subtypes of muscarinic ACh receptors (MAChRs), Ml and M3 receptors have been shown to efficiently activate PLD (and PKC) in various cell types [ 26 27 28 29 30 ] , whereas activation of PLD by M2 and M4 receptors is less robust [ 26 ] . These observations suggest that in a cholinergic synapse, ACh released into the synaptic cleft might stimulate PLD activity leading to a release of choline that could be used for ACh synthesis.
Similar selective effects have been observed on other residues including W183, W89, F107 and E106 among others [ 20 21 25 26 ] . Our data in conjunction with those of other laboratories indicates the differences in orientation of different ligands within the same binding cleft.
In summary, the β7-β8 loop of p51 is an important structural element involved in imparting stability to the heterodimer and in opening the polymerase cleft of p66 for catalysis.
Despite the fact that p51 shares an identical amino acid sequence with the N-terminal portion of p66, the two subunits assume different global folding patterns in the formation of the asymmetric heterodimer [ 9 ] . Structural determination through X-ray crystallography has revealed that the p66 subunit of HIV-1RT has its polymerase domain in an "open" conformation, with its subdomains forming a large cleft which accommodates DNA.
The structure of an AAA protomer includes an ATP-binding site located in the cleft between a large α/β N-subdomain and a smaller all-α C-subdomain.
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