Words similar to cleft

Example sentences for: cleft

How can you use “cleft” in a sentence? Here are some example sentences to help you improve your vocabulary:

However, the DPBBs from the two DDRP subunits are spatially juxtaposed in the DDRP crystal, with the catalytic cleft located between them.
Examination of the crystal structure of HIV-1 RT reveals the presence of a small groove like region on the floor of the polymerase cleft of p66 [ 11 ] . The β7-β8 loop of p51, comprising of six amino acids denoted as SINNET appears to fit into this groove-like region and likely stabilizes the polymerase domain of p66.
The α subunit further stabilizes this cleft, whereas the ω subunit interacts with the β' subunit [ 7 ] . Given their ubiquitous presence in all cellular life forms and high level of sequence conservation, it seems evident that the core subunits of this complex RNA synthesis machine were already present in the last universal common ancestor (LUCA) of the extant cellular life forms and performed functions mechanistically similar to those of modern DDRP.
The bacterial DDRPs have two α-subunits that form a homodimer at the "base" of the β-β' dimer and stabilize the catalytic-binding cleft.
In summary, the β7-β8 loop of p51 is an important structural element involved in imparting stability to the heterodimer and in opening the polymerase cleft of p66 for catalysis.