Words similar to cleaved
Example sentences for: cleaved
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It is well established that specific intracellular autoantigens are cleaved into different fragments in Jurkat T cells and other cell types undergoing apoptosis and necrosis [ 20 ] . Mancini et al . reported that golgin-160 (native protein, 160 kDa) was cleaved into a 140 kDa fragment during apoptosis [ 29 ] . We therefore performed an immunoblotting analysis using extracts from Jurkat cells treated with apoptosis-inducing reagent (1 μM STS) or necrosis-inducing reagent (0.
The processing of golgin-160 and giantin occurred as early as that for PARP, suggesting that these proteins are cleaved during the onset of apoptosis (data not shown).
This was further supported by the demonstration that trypsin cleaved PP5 in the "hinge" sequence connecting the TPR region and catalytic domain, and that such cleavage produced a highly active enzyme which was refractory to further activation by fatty acids [ 18 20 21 ] . To test whether this is also true of PfPP5, we digested recombinant PfPP5 with trypsin, which resulted in the production of a trypsin-resistant fragment that was very similar in size to ΔTPR-PfPP5 (Fig.
3, right), PARP was cleaved into an 89 kDa polypeptide (apoptotic fragments) or 60 and 50 kDa polypeptides (necrotic fragments), respectively, with complete degradation of native protein as previously described [ 24 ] . Golgin-160 was cleaved into 140 and 80 kDa fragments in apoptotic cells, consistent with published observations [ 29 ] . In contrast to the apoptotic fragments, a 70 kDa fragment was detected in necrotic cells.
Procaspase 7 began to be cleaved at 1 h of treatment and was completely processed by 3 h of treatment in both BRCA1 wt and BRCA1+ cells.
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