Words similar to chemotactic
Example sentences for: chemotactic
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Another chemokine that has been associated with Coll I production is monocyte chemotactic protein 1 (MCP-1).
The chemotactic cytokines, or chemokines, compose a large superfamily of small structurally related polypeptides that play important roles in host defense by recruiting specific subsets of leukocytes to sites of inflammation and injury [ 6 ] . Chemokines have been associated with a number of inflammatory diseases and conditions, including asthma, sepsis, inflammatory bowel disease, and adult respiratory distress syndrome [ 7 8 9 ] . The chemokine superfamily can be divided into two major groups based on the position of the first two of four-conserved cysteine residues at the amino terminus, which are either adjacent (CC subfamily) or separated by one amino acid (CXC subfamily).
Activated neutrophils have also been reported to express increased macrophage inflammatory protein-2 (MIP-2) mRNA following endotoxin administration [ 21 ] . It is possible that the secondary increase in adherent neutrophils in the lung vasculature is due to the generation of chemotactic factors by activated neutrophils.
The number of concentrations tested per assay was limited by the 48 wells (16 combinations for triplicate wells), but in separate assays we have seen significant chemotactic activity at mactinin concentrations as low as 0.5 nM.
This is in agreement with other studies showing lack of CCL2 binding to blood neutrophils and general lack of chemotactic response of these cells to CC chemokines [ 26 ] , although recent reports indicate that neutrophils, in response to certain cytokines, are capable of expressing CC chemokine receptors [ 27 28 ] .
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