Words similar to chemotactic
Example sentences for: chemotactic
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Activated neutrophils have also been reported to express increased macrophage inflammatory protein-2 (MIP-2) mRNA following endotoxin administration [ 21 ] . It is possible that the secondary increase in adherent neutrophils in the lung vasculature is due to the generation of chemotactic factors by activated neutrophils.
The chemotactic cytokines, or chemokines, compose a large superfamily of small structurally related polypeptides that play important roles in host defense by recruiting specific subsets of leukocytes to sites of inflammation and injury [ 6 ] . Chemokines have been associated with a number of inflammatory diseases and conditions, including asthma, sepsis, inflammatory bowel disease, and adult respiratory distress syndrome [ 7 8 9 ] . The chemokine superfamily can be divided into two major groups based on the position of the first two of four-conserved cysteine residues at the amino terminus, which are either adjacent (CC subfamily) or separated by one amino acid (CXC subfamily).
To determine whether acute endotoxemia activated adherent vascular lung neutrophils for increased functional responsiveness, we initially analyzed their chemotactic activity towards bacterially-derived fMLP.
IGF-I produces a chemotactic response in human melanoma cells and antisense to the IGF-IR mRNA prevents metastasis in the murine carcinoma cell H-59.
Another chemokine that has been associated with Coll I production is monocyte chemotactic protein 1 (MCP-1).