Words similar to chemopreventive
Example sentences for: chemopreventive
How can you use “chemopreventive” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the present study we used a carcinogen-induced rat mammary carcinogenesis model to test the hypothesis that chemoprevention by tamoxifen and retinoids is associated with local upregulation of TGF-βs in the mammary gland, and that TGF-βs might therefore be useful as potential surrogate end-point biomarkers of chemopreventive efficacy in clinical trials.
It is estimated that 1.2 million new cases of non-melanoma skin cancer occur each year in the United States, and the majority of these are believed to result from heavy exposure to ultraviolet (UV) light from the sun [ 1 ] . The incidence of skin cancer is predicted to increase even further because of the depletion of the stratospheric ozone layer [ 2 ] . The development of chemopreventive strategies for skin cancer is thus a high public health priority.
The mean weights of the rats in the various experimental groups differed by less than 10% from those of rats not treated with a chemopreventive agent, except for the rats treated with a combination of tamoxifen and 4-HPR, in which the mean weight was approximately 15% lower than the that in untreated group by the end of the study (Fig.
While the evaluation of aspirin in the Min /+ model utilising a therapeutic regime is lacking, other NSAIDs (sulindac, flurbiprofen, piroxicam and celecoxib) have been shown to significantly reduce polyp numbers when administered using similar protocols [ 6 11 34 35 ] . In addition, three recent reports have demonstrated a lack of effect of aspirin as a chemopreventive agent in Min /+ mice [ 36 37 38 ] . Combined, these studies indicate that the Min /+ model is responsive to NSAIDs other than aspirin when provided as a treatment.
Effect of chemopreventive agents on the histology of the mammary gland
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