Example sentences for: chemokines

How can you use “chemokines” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Experiments with blocking mAbs were carried out to examine the chemokines in the supernatants of SCL that accounted for monocyte migration.

  • Evidence has accumulated to suggest that chemokines, such as CXCL8 (IL-8), CXCL5 (epithelial cell-derived neutrophil-activating protein), CCL2 (monocyte chemoattractant protein-1), CCL3 (macrophage inflammatory protein-1α) and CCL5 (RANTES), direct the migration of leukocytes into the RA synovium and joint fluid [ 8 ] . Chemokines occur in significantly elevated levels in human RA synovial fluid, where they are biologically active, and are expressed by cells of the synovium and cartilage.

  • ELR +CXC chemokines are potent angiogenic factors, whereas ELR -CXC chemokines are potent angiostatic factors.

  • These include the immediate early response genes Fos, Jun, and Myc, as well as inhibitors of apoptosis (IAP-2), chemokines (Gro-1) and the inhibitor of NFκB, IκB-alpha.

  • However, recent studies have indicated that large numbers of virus-specific CD8 +T cells preferentially accumulate in the synovial fluid of RA patients and that these cells are also oligoclonal, suggesting that non-antigen-specific homing may be responsible for the observed oligoclonality of CD8 +T cells in the synovial fluid [ 6 ] . Because chemokines such as macrophage inflammatory protein-1α and RANTES (regulated upon activation, normal T-cell expressed and secreted) are expressed in RA synovial tissue [ 7 8 ] , subsets of CD8 +T cells may be preferentially recruited into the synovial tissue in a non-antigen-specific manner.


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