Words similar to chemoprevention
Example sentences for: chemoprevention
How can you use “chemoprevention” in a sentence? Here are some example sentences to help you improve your vocabulary:
Immunohistochemical staining was done using rabbit polyclonal antibodies raised against synthetic peptides that correspond to regions in the mature forms of TGF-β 1 , TGF-β 2 , and TGF-β 3 . Antibodies to TGF-β 1 were raised against a synthetic peptide corresponding to residues 1-30 of the mature protein in either the Laboratory of Chemoprevention (anti-TGF-β 1 -LC; NIH, Bethesda, MD, USA) or the Collagen Corporation (anti-TGF-β 1 -CC; Palo Alto, CA, USA).
Given the very limited breast tissue available in clinical chemoprevention trials, we do not recommend testing for TGF-βs as surrogate end-point biomarkers at this time.
In the present study we used a carcinogen-induced rat mammary carcinogenesis model to test the hypothesis that chemoprevention by tamoxifen and retinoids is associated with local upregulation of TGF-βs in the mammary gland, and that TGF-βs might therefore be useful as potential surrogate end-point biomarkers of chemopreventive efficacy in clinical trials.
Although we cannot rule out more subtle effects on TGF-β activity, such as the activation of latent forms, the data suggest that TGF-βs are not involved in the underlying molecular mechanism of chemoprevention induced by these agents.
Although there is a growing body of epidemiological evidence on the role of aspirin and other NSAIDs in the chemoprevention of lung cancer (Table 1.; [ 14 17 18 19 20 21 22 23 ] ), about half of these studies published to date were not specifically designed to investigate this association [ 17 18 19 21 ] . In a randomized trial aimed at examining the effect of aspirin in the prevention of cardiovascular disease in male physicians, Peto et al [ 17 ] first noted lower lung cancer mortality rates in the aspirin intervention group compared to the placebo group.
Loading...