Example sentences for: chemoprevention

How can you use “chemoprevention” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In conclusion, we have shown that treatment of rats with tamoxifen or retinoids results in effective chemoprevention of mammary tumorigenesis, without any detectable effect on local expression of TGF-βs.

  • The NMU-induced rat model of mammary tumorigenesis is widely used for chemoprevention studies and yields rapid development of hormonally responsive mammary tumors with 100% incidence [ 2, 4, 18].

  • Although we cannot rule out more subtle effects on TGF-β activity, such as the activation of latent forms, the data suggest that the underlying molecular mechanism of chemoprevention by these agents does not involve increases in TGF-β expression.

  • In the present study we used a carcinogen-induced rat mammary carcinogenesis model to test the hypothesis that chemoprevention by tamoxifen and retinoids is associated with local upregulation of TGF-βs in the mammary gland, and that TGF-βs might therefore be useful as potential surrogate end-point biomarkers of chemopreventive efficacy in clinical trials.

  • The American Cancer Society has indicated that cancer incidence rates are on the decline, however, they estimate that greater than 1.2 million new cases will be diagnosed this year [ 1 ] . Of these new cases, it is expected that colorectal cancers will comprise approximately 10-11% [ 1 ] . With staggering numbers as these, it is not surprising that chemoprevention has been proposed as a viable strategy to fight cancer.


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