Example sentences for: chemoprevention

How can you use “chemoprevention” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although we cannot rule out more subtle effects on TGF-β activity, such as the activation of latent forms, the data suggest that TGF-βs are not involved in the underlying molecular mechanism of chemoprevention induced by these agents.

  • Given the very limited breast tissue available in clinical chemoprevention trials, we do not recommend testing for TGF-βs as surrogate end-point biomarkers at this time.

  • Chemoprevention has been defined as the use of noncytotoxic nutrients or pharmacologic agents to enhance intrinsic physiologic mechanisms that protect the organism against the development of mutant clones and their progression to malignant cancer [ 27].

  • Immunohistochemical staining was done using rabbit polyclonal antibodies raised against synthetic peptides that correspond to regions in the mature forms of TGF-β 1 , TGF-β 2 , and TGF-β 3 . Antibodies to TGF-β 1 were raised against a synthetic peptide corresponding to residues 1-30 of the mature protein in either the Laboratory of Chemoprevention (anti-TGF-β 1 -LC; NIH, Bethesda, MD, USA) or the Collagen Corporation (anti-TGF-β 1 -CC; Palo Alto, CA, USA).

  • In conclusion, we have shown that treatment of rats with tamoxifen or retinoids results in effective chemoprevention of mammary tumorigenesis, without any detectable effect on local expression of TGF-βs.


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