Words similar to chemoprevention
Example sentences for: chemoprevention
How can you use “chemoprevention” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the present study we used a carcinogen-induced rat mammary carcinogenesis model to test the hypothesis that chemoprevention by tamoxifen and retinoids is associated with local upregulation of TGF-βs in the mammary gland, and that TGF-βs might therefore be useful as potential surrogate end-point biomarkers of chemopreventive efficacy in clinical trials.
Although we cannot rule out more subtle effects on TGF-β activity, such as the activation of latent forms, the data suggest that the underlying molecular mechanism of chemoprevention by these agents does not involve increases in TGF-β expression.
In conclusion, we have shown that treatment of rats with tamoxifen or retinoids results in effective chemoprevention of mammary tumorigenesis, without any detectable effect on local expression of TGF-βs.
Laboratory investigations support the capability of citrus peel or its major constituents, d-limonene, and also the ability of tea extract or its constituents, tea polyphenols to reduce not only the incidence and tumor size of chemically-induced tumors at several sites [ 4 8 9 17 18 20 22 ] but also the growth of various tumor cells in culture [ 11 33 ] . Both d-limonene, representative of citrus peel, and tea polyphenols, representative of black tea, are known to impact antiproliferative effects, including apoptosis, on neoplastic cells [ 4 34 35 36 37 ] . Dietary d-limonene has been shown to be effective in the chemoprevention and chemotherapy of cancer.
The NMU-induced rat model of mammary tumorigenesis is widely used for chemoprevention studies, and yields rapid development of hormonally responsive mammary tumors with 100% incidence [ 2, 4, 18].
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