Words similar to chemoprevention
Example sentences for: chemoprevention
How can you use “chemoprevention” in a sentence? Here are some example sentences to help you improve your vocabulary:
Laboratory investigations support the capability of citrus peel or its major constituents, d-limonene, and also the ability of tea extract or its constituents, tea polyphenols to reduce not only the incidence and tumor size of chemically-induced tumors at several sites [ 4 8 9 17 18 20 22 ] but also the growth of various tumor cells in culture [ 11 33 ] . Both d-limonene, representative of citrus peel, and tea polyphenols, representative of black tea, are known to impact antiproliferative effects, including apoptosis, on neoplastic cells [ 4 34 35 36 37 ] . Dietary d-limonene has been shown to be effective in the chemoprevention and chemotherapy of cancer.
In conclusion, we have shown that treatment of rats with tamoxifen or retinoids results in effective chemoprevention of mammary tumorigenesis, without any detectable effect on local expression of TGF-βs.
In the present study we used a carcinogen-induced rat mammary carcinogenesis model to test the hypothesis that chemoprevention by tamoxifen and retinoids is associated with local upregulation of TGF-βs in the mammary gland, and that TGF-βs might therefore be useful as potential surrogate end-point biomarkers of chemopreventive efficacy in clinical trials.
Although we cannot rule out more subtle effects on TGF-β activity, such as the activation of latent forms, the data suggest that TGF-βs are not involved in the underlying molecular mechanism of chemoprevention induced by these agents.
Although there is a growing body of epidemiological evidence on the role of aspirin and other NSAIDs in the chemoprevention of lung cancer (Table 1.; [ 14 17 18 19 20 21 22 23 ] ), about half of these studies published to date were not specifically designed to investigate this association [ 17 18 19 21 ] . In a randomized trial aimed at examining the effect of aspirin in the prevention of cardiovascular disease in male physicians, Peto et al [ 17 ] first noted lower lung cancer mortality rates in the aspirin intervention group compared to the placebo group.
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