Words similar to chemoprevention
Example sentences for: chemoprevention
How can you use “chemoprevention” in a sentence? Here are some example sentences to help you improve your vocabulary:
The NMU-induced rat model of mammary tumorigenesis is widely used for chemoprevention studies, and yields rapid development of hormonally responsive mammary tumors with 100% incidence [ 2, 4, 18].
Immunohistochemical staining was done using rabbit polyclonal antibodies raised against synthetic peptides that correspond to regions in the mature forms of TGF-β 1 , TGF-β 2 , and TGF-β 3 . Antibodies to TGF-β 1 were raised against a synthetic peptide corresponding to residues 1-30 of the mature protein in either the Laboratory of Chemoprevention (anti-TGF-β 1 -LC; NIH, Bethesda, MD, USA) or the Collagen Corporation (anti-TGF-β 1 -CC; Palo Alto, CA, USA).
Laboratory investigations support the capability of citrus peel or its major constituents, d-limonene, and also the ability of tea extract or its constituents, tea polyphenols to reduce not only the incidence and tumor size of chemically-induced tumors at several sites [ 4 8 9 17 18 20 22 ] but also the growth of various tumor cells in culture [ 11 33 ] . Both d-limonene, representative of citrus peel, and tea polyphenols, representative of black tea, are known to impact antiproliferative effects, including apoptosis, on neoplastic cells [ 4 34 35 36 37 ] . Dietary d-limonene has been shown to be effective in the chemoprevention and chemotherapy of cancer.
Given the very limited breast tissue available in clinical chemoprevention trials, we do not recommend testing for TGF-βs as surrogate end-point biomarkers at this time.
Although we cannot rule out more subtle effects on TGF-β activity, such as the activation of latent forms, the data suggest that TGF-βs are not involved in the underlying molecular mechanism of chemoprevention induced by these agents.
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