Words similar to cftr
Example sentences for: cftr
How can you use “cftr” in a sentence? Here are some example sentences to help you improve your vocabulary:
Phenotypic expression is variable in patients carrying homozygous or heterozygous mutations of the CFTR gene.
For example, an increase in asialo-GM 1 glycoproteins on the apical surface of CF airway epithelial cells provides greater opportunity for adhesion by the type IV pili of P. aeruginosa [ 3 7 8 ] . Furthermore, the first extracellular domain of wild type CFTR has been found to act as a P. aeruginosa -specific receptor, which is involved in the clearance of P. aeruginosa from the airways via epithelial cell desquamation [ 9 10 11 ] , a process greatly impaired in the CF lung.
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the CFTR chloride channel [ 1 ] . CFTR is known to possess multiple cellular functions beyond its role as an apical membrane chloride channel [ 2 ] . For example, regulation of other ion channels, such as the epithelial sodium channel and the outwardly rectified chloride channel, are well-described functions of CFTR [ 3 4 ] . Numerous other functions, such as regulation of intracellular vesicular pH, regulation of membrane recycling, and regulation of mucin exocytosis are less firmly established.
The correlation between zygosity and level of IBAT protein expression suggests a close relationship between the function of the CFTR chloride channel and the sodium-dependent ileal bile acid transporter.
CFTR regulation of ENaC has been described in the colon in humans [ 37 ] and in cftr knockout mice [ 37 ] . Co-localization of CFTR and ENaC suggests that direct protein-protein interactions allow CFTR to closely regulate the activity of this channel [ 39 40 ] . Our results suggest that knockout of CFTR leads to an analogous increase in expression and function of IBAT.
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