Words similar to cftr

Example sentences for: cftr

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An alternative mechanism for the upregulation of IBAT in cystic fibrosis is that CFTR acts as a negative regulator of IBAT, as it does for the epithelial sodium channel [ 36 ] . As IBAT is a sodium-dependent apical membrane transporter, it might be regulated by CFTR, as is the epithelial sodium channel (ENaC) present in the apical membrane of the ileal enterocyte.
Additional studies should examine changes in mucus layer thickness, mucus viscosity and permeability for bile acids associated with hetero- and homozygosity for CFTR mutations.
Likewise, there was an inverse relationship found between the length of the polythimidine tract, which influences the acceptor strength, at the exon 9 acceptor site and the proportion of exon 9 deleted CFTR mRNA transcripts [ 23 ] . Our results indicate that acceptor splice site strength is an important parameter in the regulation of NF1 splicing.
The ΔF508 mutation is the most common genetic disturbance affecting the CFTR gene.
CFTR regulation of ENaC has been described in the colon in humans [ 37 ] and in cftr knockout mice [ 37 ] . Co-localization of CFTR and ENaC suggests that direct protein-protein interactions allow CFTR to closely regulate the activity of this channel [ 39 40 ] . Our results suggest that knockout of CFTR leads to an analogous increase in expression and function of IBAT.