Words similar to cftr
Example sentences for: cftr
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Of course, a more widespread perturbation of ion channel regulation in the absence of CFTR is also a possibility, as CFTR has been demonstrated to be a master regulator of such diverse proteins as the Na/K pump [ 41 ] , the basolateral Na/K/2Cl co-transporter [ 42 ] , and the inducible nitric oxide synthase [ 43 ] .
Cftr knockout mice, with targeted disruption of the cftr gene created at the University of North Carolina [ 13 ] , were maintained at the University of Washington Animal Care Facility under the auspices of the UW Cystic Fibrosis Research Center.
IBAT: ileal bile acid transporter; CFTR: cystic fibrosis transmembrane conductance regulator.
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the CFTR chloride channel [ 1 ] . CFTR is known to possess multiple cellular functions beyond its role as an apical membrane chloride channel [ 2 ] . For example, regulation of other ion channels, such as the epithelial sodium channel and the outwardly rectified chloride channel, are well-described functions of CFTR [ 3 4 ] . Numerous other functions, such as regulation of intracellular vesicular pH, regulation of membrane recycling, and regulation of mucin exocytosis are less firmly established.
CFTR regulation of ENaC has been described in the colon in humans [ 37 ] and in cftr knockout mice [ 37 ] . Co-localization of CFTR and ENaC suggests that direct protein-protein interactions allow CFTR to closely regulate the activity of this channel [ 39 40 ] . Our results suggest that knockout of CFTR leads to an analogous increase in expression and function of IBAT.
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