Words similar to cf
Example sentences for: cf
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Other conditions that abet colonization of the CF lung include impairment of the "mucociliary escalator" and macrophage-mediated phagocytosis by the viscous airway secretions.
BSA = bovine serum albumin; CF = cystic fibrosis; CFTR = cystic fibrosis transmembrane conductance regulator; C L = lethal concentration; DMSO = dimethyl sulfoxide; EC 50 = effective concentration 50%; EDTA = ethylenediamine tetraacetic acid; GGPG = modified PG-1 with a glycine-rich hexapeptide extension (GGGYGG) containing a single tyrosine residue; HEPES = N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid; HPLC = high performance liquid chromatography; I-GGPG = monoiodinated variant of GGPG; LPS = lipopolysaccharide; MAC = minimal active concentration; PG-1 = protegrin-1; RU = resonance units; SDS = sodium dodecyl sulfate; SPR = surface plasmon resonance; TSB = trypticase soy broth.
We selected it for this study because it is rapidly bactericidal, functions well at elevated physiological salt concentrations such as those that may occur in the CF lung, and has a broad spectrum of activity [ 21 22 23 ] . PG-1's antiparallel β-hairpin structure and antimicrobial activity in physiological and elevated salt concentrations are maintained by its two intramolecular cystine disulfide bonds [ 21 24 25 26 27 28 ] . The antimicrobial spectrum of PG-1 includes Chlamydia trachomatis , Candida albicans , Escherichia coli , Fusobacterium nucleatum, Haemophilus ducreyi , Listeria monocytogenes , Neisseria gonorrhoeae , Porphyromonas gingivalis , Prevotella intermedia , P. aeruginosa , and Staphylococcus aureus [ 20 22 25 29 30 31 32 ] .
If elevated salt concentrations exist within these secretions [ 5 6 ] , they would inhibit α and β-defensins, endogenous antibacterial peptides produced by neutrophils and airway epithelia, respectively [ 2 3 12 13 14 15 ] . This last point is still under review as recent evidence suggests that CF airway surface fluid may be isotonic not hypertonic [ 16 ] .
The LAT off-leads that researchers at Boston's Beth Israel Deaconess Medical Center believe they've developed the first effective therapy for cystic fibrosis (CF).
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