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Figure 2cexamines the response of codons to GC content across individual genes within sample genomes representing all three domains of life: eukaryotes ( Drosophila ), bacteria ( Synechocystis ), and archaea ( Archaeoglobus ). The codon frequency in individual genes seems to be predictable on the basis of the overall GC content of the coding sequences: the relative GC content of individual codons explains about half the variance in response in their absolute frequencies within each coding sequence (that is, the presence or absence of a particular codon depends on the extent to which alternative synonyms of more 'suitable' GC content exist).