Words similar to ch
Example sentences for: ch
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This is consistent with evidence for the occurrence on Ch6p of multiple distinct susceptibility genes for patterns of immunoglobulin deficiency, some recessive and others dominant [ 20 ] . For example, at least two putative alleles associated with heritable IgA deficiency occur on Ch6p, and each is associated with a different major histocompatibility (MHC) region haplotype [ 22 23 ] , whereas a putative susceptibility locus on chromosome 18 is not a major contributor to selective IgA deficiency [ 24 ] . Allele(s) on chromosomes other than Ch6p may also influence the phenotypic expression of CVID and IgGSD in adults.
On the basis of observations [ 12 13 ] discussed above, one would expect AppppA with two phosphorothioadenosyl substituents to be a slow substrate with a relatively low K m . However, carbon in place of the β phosphorus (for example in 6b ) would make the leaving group the alkoxide - OCH 2 -CH(OH)-CH 2 O-phosphorothioadenosyl rather than α-thio ATP.
CTAP in this position interacts with gp120 through both hydrogen bonding (residues R311 and R315) and hydrophobic forces (F317) with two CH 3 CO- units of CTAP.
Analysis of biophores #1, #2 (#4, #5) showed that both of them occur in substituted 5-[4-(benzyloxy) phenyl]-1,3,4-oxadiazol-2-(3H)-ones and their analogs (Figure 1), many of which are known to be strong MAO-B inhibitors [ 9 ] . Biophore #2 represents a flexible -CH 2 O- bridge between aryl moieties and was found to enhance the activity and selectivity of the inhibitors as shown in the original work [ 9 ] . Biophores #1 and #2 include aromatic moieties, whose main function is presumably to bind to the hydrophobic site of MAO.
While compound 14b, containing two phosphorothioylated branches without adenosine, was barely a submicromolar inhibitor, compounds 12b and 13b, which contain respectively three and four CH 2 -phosphorothioadenosyl groups bonded to the central carbon were 40 nM and 65 nM inhibitors.
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