Example sentences for: centromeric

How can you use “centromeric” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The work of Moser et al [ 14] provided the initial evidence that the susceptibility locus in this region might lie centromeric of PARP.

  • Sonicated salmon sperm DNA (Sigma) at the same concentration was included when human sequence centromeric probes were used.

  • Fourth, MeCP2 action on chromatin, as suggested by observed changes in histone acetylation [ 31 32 ] , may not involve protein coding genes that are represented on microarrays, but instead, may affect centromeric heterochromatin or the expression of small non-coding RNAs that are abundant in normal brain [ 33 ] . The results presented in this paper contradict the established model of MeCP2 function and necessitate a rethinking of strategies to unravel the pathologic process that leads to neuronal dysfunction in Rett syndrome.

  • Physiological experiments can also be used to characterize heterochromatin-binding proteins [ 45 ] . For example, absence of Swi6 in fission yeast sensitizes cells to thiabendazole (TBZ), a microtubule depolymerizing drug [ 46 ] . Presumably this occurs because absence of Swi6 disrupts centromeric heterochromatin and, as a result, sensitizes cells to drugs that compromise spindle function.

  • Selective isolation of centromeric regions


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