Words similar to centrosomes
Example sentences for: centrosomes
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Based on studies involving compounds that alter microtubular kinetics and induce both cell-cycle delay and aneuploidy, several groups have proposed that temporal perturbations during mammalian oocyte maturation (OM) predispose oocytes to aneuploidy [ 3 4 5 6 ] . In addition to faulty microtubule kinetics, perturbations during OM may also stem from abnormal function of centrosomes, kinetochores, spindle checkpoints proteins, the anaphase-promoting complex (APC), the securin-separin-cohesion complex proteins, and the proteasome [ 7 ] .
The coiled-coil motif has also been identified in a variety of proteins associated with centromeres, centrosomes, the nuclear matrix, and chromatin [ 10 11 12 13 14 ] . TPR, a protein associated with the inner filaments of the nuclear pore complex is an extended coiled-coil protein [ 15 ] . The filamentous structures associated with both the outer and inner surface of the nuclear pore complex suggest that additional unknown coiled-coil proteins might be involved in its assembly.
It associates specifically with unduplicated centrosomes, and its phosphorylation by CDK-2/cyclin E, the trigger for centrosome duplication, is required for duplication to occur [ 17 ] . The nucleophosmin gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in cases of this disease with (2;5)(p23;q35) translocations [ 18 ] . The nucleophosmin portion contributes to transformation by providing a dimerization domain, which allows activation of the fused kinase and signal transduction [ 19 ] .
In addition, centrosomes play an important role in MT organization in animals whereas plants have no well-defined centrosomes.
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