Words similar to cell-mediated
Example sentences for: cell-mediated
How can you use “cell-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:
There is accumulating evidence that, in addition to activation-induced cell death or anergy, T-cell-mediated dominant control of self-reactive T cells represents one mechanism for maintaining immunological tolerance [ 1 2 3 ] . Studies conducted in a number of experimental models have demonstrated the existence of regulatory T-cell subsets that prevent activation of autoreactive T cells.
Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by lymphocytic infiltration of the pancreatic islets of Langerhans with subsequent destruction of the insulin-producing beta cells [ 1 ] . Non-obese diabetic (NOD) female mice, a murine model for T1DM, spontaneously develop diabetes by 30 weeks-of-age, with infiltrating cells appearing around the pancreatic islets as early as at 3-4 weeks-of-age [ 2 ] .
These factors include abnormalities in humoral and cell-mediated immunity, phagocytic cell dysfunction, and skin and mucous membrane defects [ 3 ] . The presence of neutropenia [ 4 5 ] use of central venous catheters [ 4 6 ] , low CD4 +lymphocyte count, and intravenous drug use [ 6 ] are cited as risk factors for bacteremic infections in patients with HIV infection.
Other factors that may contribute include functional defects in antigen-specific cell-mediated immunity [35,37,40,41,42], and progressive immune escape [43,44,45].
SLC/CCL21, a CC chemokine expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts naive T cells and DCs [ 1 2 3 4 5 6 7 8 ] . Because DCs are potent APCs that function as principal activators of T cells, the capacity to facilitate the co-localization of both DC and T cells may reverse tumor-mediated immune suppression and orchestrate effective cell-mediated immune responses [ 9 10 25 26 27 ] . In addition to its immunotherapeutic potential, SLC/CCL21 has been found to have potent angiostatic effects [ 28 ] , thus adding further support for its use in cancer therapy.
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