Words similar to cell-mediated
Example sentences for: cell-mediated
How can you use “cell-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:
There is accumulating evidence that, in addition to activation-induced cell death or anergy, T-cell-mediated dominant control of self-reactive T cells represents one mechanism for maintaining immunological tolerance [ 1 2 3 ] . Studies conducted in a number of experimental models have demonstrated the existence of regulatory T-cell subsets that prevent activation of autoreactive T cells.
Fibronectin matrix assembly is a cell-mediated process that requires the activity of integrins [ 1 6 7 8 ] . The integrin that is primarily responsible for assembling fibronectin into the matrix is α5β1, although αvβ3, αllbβ3 and α4β1 can also function in this capacity [ 9 10 11 12 13 14 ] . In addition to integrins, fibronectin matrix assembly also depends on self-association sites within fibronectin.
SLC/CCL21, a CC chemokine expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts naive T cells and DCs [ 1 2 3 4 5 6 7 8 ] . Because DCs are potent APCs that function as principal activators of T cells, the capacity to facilitate the co-localization of both DC and T cells may reverse tumor-mediated immune suppression and orchestrate effective cell-mediated immune responses [ 9 10 25 26 27 ] . In addition to its immunotherapeutic potential, SLC/CCL21 has been found to have potent angiostatic effects [ 28 ] , thus adding further support for its use in cancer therapy.
One mechanism by which tumors evade immune destruction is through cytokine production or induction [ 1 ] . Prostaglandin E-2 (PGE-2), constitutively produced by many NSCLC has been identified as one factor that has direct immunosuppressive properties and is known to induce IL10 in mononuclear cells [ 2 3 4 5 6 7 ] . IL10 is a dominant immunosuppressive cytokine found in the NSCLC environment known to directly affect T cell-mediated immunity [ 2 3 4 5 6 7 8 9 10 11 12 ] . Both PGE-2 and IL10 have been shown to suppress antigen presentation, to suppress cytotoxic T cell (CTL) responses, and to inhibit cytokine production by T cells and antigen presenting cells, perhaps most importantly IL12, that plays a central role in initiation and potentiation of cellular immune responses [ 2 3 4 5 6 7 ] , [ 11 12 13 14 15 16 17 18 19 ] . We asked whether PGE-2 levels and/or IL10 levels were elevated in plasma of NSCLC patients, whether monocytes from NSCLC patients produce more IL10 than normals, and whether there was correlation within our findings.
Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by lymphocytic infiltration of the pancreatic islets of Langerhans with subsequent destruction of the insulin-producing beta cells [ 1 ] . Non-obese diabetic (NOD) female mice, a murine model for T1DM, spontaneously develop diabetes by 30 weeks-of-age, with infiltrating cells appearing around the pancreatic islets as early as at 3-4 weeks-of-age [ 2 ] .
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