Words similar to cell-mediated
Example sentences for: cell-mediated
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SLC/CCL21, a CC chemokine expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts naive T cells and DCs [ 1 2 3 4 5 6 7 8 ] . Because DCs are potent APCs that function as principal activators of T cells, the capacity to facilitate the co-localization of both DC and T cells may reverse tumor-mediated immune suppression and orchestrate effective cell-mediated immune responses [ 9 10 25 26 27 ] . In addition to its immunotherapeutic potential, SLC/CCL21 has been found to have potent angiostatic effects [ 28 ] , thus adding further support for its use in cancer therapy.
One mechanism by which tumors evade immune destruction is through cytokine production or induction [ 1 ] . Prostaglandin E-2 (PGE-2), constitutively produced by many NSCLC has been identified as one factor that has direct immunosuppressive properties and is known to induce IL10 in mononuclear cells [ 2 3 4 5 6 7 ] . IL10 is a dominant immunosuppressive cytokine found in the NSCLC environment known to directly affect T cell-mediated immunity [ 2 3 4 5 6 7 8 9 10 11 12 ] . Both PGE-2 and IL10 have been shown to suppress antigen presentation, to suppress cytotoxic T cell (CTL) responses, and to inhibit cytokine production by T cells and antigen presenting cells, perhaps most importantly IL12, that plays a central role in initiation and potentiation of cellular immune responses [ 2 3 4 5 6 7 ] , [ 11 12 13 14 15 16 17 18 19 ] . We asked whether PGE-2 levels and/or IL10 levels were elevated in plasma of NSCLC patients, whether monocytes from NSCLC patients produce more IL10 than normals, and whether there was correlation within our findings.
These factors include abnormalities in humoral and cell-mediated immunity, phagocytic cell dysfunction, and skin and mucous membrane defects [ 3 ] . The presence of neutropenia [ 4 5 ] use of central venous catheters [ 4 6 ] , low CD4 +lymphocyte count, and intravenous drug use [ 6 ] are cited as risk factors for bacteremic infections in patients with HIV infection.
Other factors that may contribute include functional defects in antigen-specific cell-mediated immunity [35,37,40,41,42], and progressive immune escape [43,44,45].
The differential binding of peptides to diverse MHC molecules during cell-mediated immune response has been fairly established using MHC-peptide structural data obtained by X-ray crystallography.
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