Words similar to cell-fate
Example sentences for: cell-fate
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The hedgehog ( hh ) gene was identified two decades ago in Drosophila as a critical regulator of cell-fate determination during embryogenesis [ 1 ] . Subsequent work in several model systems has defined and characterized the Hh gene family that encodes highly conserved secreted signaling proteins (for review see [ 2 ] ). Hedgehog (Hh) proteins are synthesized as approximately 45 kDa precursors that autoprocess in an unprecedented fashion, resulting in the covalent attachment of a cholesterol moiety to the amino-terminal half of the precursor [ 2 ] . This processed amino-terminal domain, Hh-Np, is responsible for the activation of a unique and complex signaling cascade that is essential for controlling cell fate throughout development and into adulthood [ 2 ] . In mammals there are three Hh-family proteins: Sonic (Shh), Indian (Ihh), and Desert (Dhh).
Cell-fate changes that occur during development are almost always accompanied by changes in gene expression.
With intrinsic factors, unequal amounts of cell-fate determinants are distributed into the two cells prior to their separation [ 29 ] . Among the intrinsic factors underlying asymmetric division, the interactions of the Numb differentiation-associated protein with Notch proliferation-associated signaling is the model most widely studied, ranging from bacteria, yeast, and Drosophila to mammals [ 30 ] . Mammalian cells known to exhibit asymmetric division include diverse cell types such as neuronal cells, thymocytes, and satellite cells involved in myogenesis, and the list is growing [ 29 30 31 32 ] .
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