Words similar to cell-matrix
Example sentences for: cell-matrix
How can you use “cell-matrix” in a sentence? Here are some example sentences to help you improve your vocabulary:
For the disruption of cell-matrix interactions, cells grown as a monolayer were either trypsinized or scraped off the culture dish and dispersed by pipetting.
In light of the close correlation between the anchorage-independent phenotype and the tumorigenicity of transformed cells, it is important to fully understand the cellular mechanisms that are involved in cell growth arrest after the disruption of cell-matrix interactions.
In view of PTEN's potent growth-inhibitory capacity, we conclude that its induction after cell-matrix disruptions contributes to the maintenance of the anchorage-dependent phenotype of normal cells.
This protein acts as inhibitor of cyclin-dependent kinases (the "cell cycle engine" [ 50 ] ), and its elevated expression has been consistently demonstrated in different cell types after the disruption of cell-matrix interactions (compare Figure 1and [ 31 32 51 52 ] ). Furthermore, p27 Kip1is an established target of PTEN signaling, i.e., its activity has been found increased after the forced expression of exogenous PTEN [ 53 54 55 56 ] . In combination with the data presented in this manuscript, it therefore appears that PTEN contributes to anchorage-dependent growth control by a two-fold approach: the dephosphorylation of the signaling molecule FAK in combination with the stimulation of the cell cycle inhibitor p27 Kip1.
However, since SPARC is a matricellular protein involved in cell-matrix interaction [ 3 4 23 ] , cell-matrix interaction-related defects may exert a significant influence in large wounds of SPARC-null mice causing premature loss of a part of the scabs and of the neoepidermis, a pathophysiological process requiring repeated healing.
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