Words similar to cell-matrix
Example sentences for: cell-matrix
How can you use “cell-matrix” in a sentence? Here are some example sentences to help you improve your vocabulary:
In small wounds, the pathophysiological process caused by the cell-matrix interaction-related defects may be too small to affect reepithelialization significantly with the result that restoration of epidermal covering progresses as normally as in the wild-type mice.
Stabilin-1 and -2 are homologous transmembrane proteins showing 7 fasciclin-like adhesion domains, 18-20 EGF domains, 1 X-link domain and 3-6 B-X(7)-B hyaluronan-binding motifs [ 40 ] . Stabilin-1 and stabilin-2 are likely to play a role in cell-cell and cell-matrix interactions in vascular cells [ 40 ] .
Previously, studies of phenotypes in this laboratory have shown that SPARC-null mice develop osteopenia around 2.5 months of age [ 19 ] in bones where SPARC is normally the most abundant non-collagenous glycoprotein [ 3 ] . The second phenotype thus far uncovered is in the lens where SPARC is normally produced by lens epithelial cells [ 20 21 ] and is a component of the lens capsule [ 20 22 ] . SPARC-null mice show progressive cataract formation beginning approximately 1.5 months after birth [ 14 21 ] . Electron microscopy of the SPARC-null lens revealed abnormality at the lens cell-ECM (capsule) interface with an intrusion of cellular processes into the basement membrane of the lens capsule, whereas wild-type lens exhibited a precise border at the cell-matrix interface [ 23 ] . In the present study, we show for the first time that SPARC plays a role in wound repair in vivo and in vitro.
In view of PTEN's potent growth-inhibitory capacity, we conclude from our study that the increased expression and activity of endogenous PTEN in response to the disruption of cell-matrix interactions contributes to the maintenance of the anchorage-dependent phenotype of normal cells.
It should be noted that the fibroblast cells lines we used remain fully viable after detachment and transfer to suspension culture [ 31 43 ] . This is in contrast to most epithelial cells which undergo anoikis, i.e., apoptotic cell death after the disruption of cell-matrix interactions [ 45 ] . It is of interest that some anchorage-independent tumor cells, most of which are of epitheloid origin, become susceptible to anoikis after the introduction of exogenous PTEN [ 23 34 35 36 ] . These observations are in line with the established ability of PTEN to down-regulate the phosphatidylinositol 3-kinase (PI3-K)/PKB survival pathway [ 11 46 ] . The absence of anoikis in our two cell lines may reflect inherent cell type specific differences, i.e., the superior ability of fibroblasts to survive under suspension culture conditions.
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