Words similar to bcr
Example sentences for: bcr
How can you use “bcr” in a sentence? Here are some example sentences to help you improve your vocabulary:
In addition, this CD5 response to BCR stimulation has been shown to be mediated in part by vav-2, which activates of NF-AT [ 49].
In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .
Phosphorylation of Y551 and a putative autophosphorylation site Y223 in the SH3 domain of Btk [ 23, 24] are observed following BCR activation, suggesting that these tyrosine phosphorylations are functionally important for antigen receptor signaling.
In order to determine whether Btk activation alone is sufficient to mimic aspects of BCR signaling, we have generated Btk:ER, a novel conditional form of Btk.
However, in the context of signaling through the BCR, we surprisingly found that kinase inactive Btk:ER could reconstitute calcium mobilization in these Btk-deficient cells (Fig 2C).
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