Words similar to bcr
Example sentences for: bcr
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In immature B cells, activation through the BCR induces either a state of unresponsiveness, termed anergy, or death by apoptosis, depending on the physical nature and concentration of the antigen [ 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 ] . In some B cell lymphomas, activation through the BCR can induce cell cycle arrest and apoptosis in vitro and tumor dormancy in vivo [ 19 26 27 28 ] . The core of the multi-subunit BCR is membrane-bound immunoglobulin (mIg), which is non-covalently associated with two co-receptor molecules, CD79a (Igα) and CD79b (Igβ), products of the mb-1 and B29 genes [ 29 30 ] . The biochemical changes induced by engagement of the BCR are extensive and include an increase in tyrosine phosphorylation of several intracellular proteins, hydrolysis of membrane phospholipids, fluxes in the concentration of intracellular free Ca 2+, activation of several serine/threonine kinases including components of the MAP kinase pathway, and changes in the activities of a panel of transcription factors.
The anti-phosphotyrosine immunoblot used is a relatively crude measure of Syk kinase activity in vivo . The possibility remained that any specific effects of constitutive Syk on its downstream targets might be masked by the combined effects of the other tyrosine kinases activated in response to BCR signaling.
The B cell antigen receptor (BCR) is a multi-subunit complex that acts as a key sensor regulating the response of lymphocytes to their environment (reviewed in [ 1 2 3 4 5 6 7 ] ). In mature B cells, activation through the BCR stimulates cellular proliferation and differentiation.
Rlk and Itk, may therefore function together in these TCR signaling events in a fashion similar to Btk in BCR signaling.
In order to determine whether Btk activation alone is sufficient to mimic aspects of BCR signaling, we have generated Btk:ER, a novel conditional form of Btk.
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