Words similar to bcr
Example sentences for: bcr
How can you use “bcr” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although syk -deficient mice die perinatally, analysis of radiation chimeras reconstituted with fetal liver from syk -deficient mice has demonstrated a block in the transition from proB cells to preB cells, indicating that signal transduction through Syk is required for early B cell development [ 35 36 ] . Inactivation of the syk gene in the chicken DT40 B cell lymphoma leads to a loss in the activation of PLCγ2, the increase in intracellular free Ca 2+and the apoptotic response following engagement of the BCR.
The anti-phosphotyrosine immunoblot used is a relatively crude measure of Syk kinase activity in vivo . The possibility remained that any specific effects of constitutive Syk on its downstream targets might be masked by the combined effects of the other tyrosine kinases activated in response to BCR signaling.
After stimulation of BCR, many intracellular proteins became highly phosphorylated on tyrosine to equivalent levels in all clones, regardless of the level of Syk kinase activity (lanes 2, 5, 8 and 11).
Syk has also been implicated in BCR-induced apoptosis found in the chicken B lymphoma line, DT40 [ 38 ] . To determine the role of Syk kinase activation in the apoptotic response in BCL 1 .3B3, overexpression of a mutant form of Syk was used in an effort to alter the level of Syk activation following BCR engagement.
These data have led to the hypothesis that Btk co-operates with Syk in PLCγ2-dependent BCR signaling and that Btk functions as a signal duration modulator (reviewed in references [ 15, 16]).
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