Words similar to bcr

Example sentences for: bcr

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In summary, here we describe the use of a mutant Syk construct to produce a dominant-positive effect on endogenous Syk activation in the absence of BCR engagement.
BCR-mediated tyrosine kinase activation is thought to be involved in the signal transduction cascades that give rise to these changes in cell growth and viability [ 19 ] . To determine if BCR engagement under these conditions leads to Syk kinase activation, increasing amounts of anti-IgM were added to cultured BCL 1 .3B3 cells.
The increase in Syk activity in response to BCR engagement in BCL 1 .3B3 was accompanied by an increase in tyrosine phosphorylation of Syk protein in cells (Figure 2C).
In syk -deficient DT40 cells, BCR induced apoptosis was abrogated indicating that Syk was necessary for this cellular response [ 38 ] . Having established cells with constitutive Syk activity, it was now possible to establish if Syk activation is sufficient for any of the signaling responses.
However Btk:ER was clearly able to induce sustained ERK activity and this, coupled with the findings that in Btk-deficient cells the sustained response is impaired [ 9], suggest that Btk activation may be responsible for the prolonged ERK activation normally detected following BCR cross-linking.