Words similar to bcr

Example sentences for: bcr

How can you use “bcr” in a sentence? Here are some example sentences to help you improve your vocabulary:

This is not surprising since the ITAMs in CD79, which are proposed to be docking sites for Syk, are unlikely to be phosphorylated in the absence of BCR stimulation since phosphorylation of these residues likely requires activation of Src family tyrosine kinases expressed in B cells.
Surprisingly, the phosphospecific antiserum did not detect Btk:ER Y223 phosphorylation in response to BCR cross-linking, suggesting that the observed phosphorylation in this case is largely due to the Y551 Lyn transphosphorylation site.
However, the presence of Syk kinase activity was still expected to lead to increased phosphorylation of protein targets in the absence of stimulation through the BCR.
Phosphorylation of Y551 and a putative autophosphorylation site Y223 in the SH3 domain of Btk [ 23, 24] are observed following BCR activation, suggesting that these tyrosine phosphorylations are functionally important for antigen receptor signaling.
Although syk -deficient mice die perinatally, analysis of radiation chimeras reconstituted with fetal liver from syk -deficient mice has demonstrated a block in the transition from proB cells to preB cells, indicating that signal transduction through Syk is required for early B cell development [ 35 36 ] . Inactivation of the syk gene in the chicken DT40 B cell lymphoma leads to a loss in the activation of PLCγ2, the increase in intracellular free Ca 2+and the apoptotic response following engagement of the BCR.