Example sentences for: bcr

How can you use “bcr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To determine if expression of the (K395A/3F)Syk mutant resulted in a change in BCR responsiveness, the kinetics of Syk activation were measured in clones 2.1.

  • Examples include A6 kinases [ 17], a number of lipid kinase family members [ 18], aminoglycoside phosphotransferases [ 19], pyruvate dehydrogenase kinase family members [ 20], DNA-dependent protein kinase [ 21], ATM [ 22], ATR [ 23], BCR [ 24, 25], a transient receptor potential channel [ 26] and actin-fragmin kinases [ 27].

  • Apoptosis is a major biological response of B cells to BCR cross-linking and Btk is clearly necessary for this effect in DT40 cells [ 12, 13].

  • In syk -deficient DT40 cells, BCR induced apoptosis was abrogated indicating that Syk was necessary for this cellular response [ 38 ] . Having established cells with constitutive Syk activity, it was now possible to establish if Syk activation is sufficient for any of the signaling responses.

  • However, in the context of signaling through the BCR, we surprisingly found that kinase inactive Btk:ER could reconstitute calcium mobilization in these Btk-deficient cells (Fig 2C).


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