Words similar to bcl-
Example sentences for: bcl-
How can you use “bcl-” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the same time-course experiment, we assayed for the presence of Bcl-3, an IκB family member that we have previously shown to have a role in MMP-1 expression.
It is known, for example, that S. aureus α-toxin induces apoptosis in Jurkat cells via the Bcl-2-controlled mitochondrial death pathway [ 32 ] ; therefore, neutralization of TRAIL would not be expected to interfere with this mechanism of apoptosis induction.
Measures were made on twenty germ cells (within a respective section) per fetus for each analytical procedure: p53, apoptotic DNA fragmentation, 8-oxoguanine, Bcl-2, and polymerase β.
In the presence of Bcl-2, irregularities within the DNA sequence are corrected before the p53 suicidal program is executed.
Fas contains a single transmembrane domain and belongs to the tumor necrosis factor (TNF)/nerve growth factor family [ 8 ] . FasL contains a single transmembrane domain and is also a member of the same TNF family [ 9 ] . A soluble form of FasL has been described, but appears to be less capable of inducing apoptosis, when compared with the bound form [ 10 11 ] . The binding of FasL with Fas initiates receptor oligomerization, which recruits Fas-associated death domain (FADD) [ 12 ] . FADD binds procaspase-8 and permits activation of caspase-8 through self-cleavage [ 13 ] . Caspase-8 activates the effector caspases, which commits the cell to the orderly process of apoptosis [ 14 15 ] . In addition, caspase-8 cleaves Bcl-2-interactive-death-agonist (Bid) [ 16 ] . Truncated Bid localizes to the mitochondria and promotes cytochrome c release; this process also serves as a major apoptotic-signaling pathway for Fas [ 16 17 18 ] . Depending upon the amount of caspase-8 that is activated, the predominant pathway can be either Bid cleavage with subsequent mitochondrial release of cytochrome c or activation of the effector caspase pathway [ 18 ] . Resident cells of the kidney express both Fas and FasL and Fas/FasL signaling is functional in these cells [ 19 20 21 22 23 24 ] . A recent review by Ortiz and associates [ 25 ] noted that the combined literature demonstrating participation of Fas/FasL pathway in renal injury essentially fulfilled Koch's postulates.