Words similar to bcr-induced

Example sentences for: bcr-induced

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These proteins are unlikely to include Lyn or Syk, the two PTKs that are primarily responsible for the BCR-induced tyrosine phosphorylation pattern seen in DT40 whole cell lysates [ 14], since we were unable to detect phosphorylation of Lyn and Syk following specific immunoprecipitations (data not shown).
BCR-induced interaction between Cbl and Syk increases the susceptibility of Syk to proteolysis [ 55 ] , possibly through enhancement of ubiquitination [ 56 ] . Expression of a dominant-negative SHP-1 phosphatase in the mature murine B cell line K46 resulted in an increase in BCR-induced Syk kinase activity as measured by C3b phosphorylation in an ICKA and enhanced BCR-induced Ca 2+fluxes [ 57 ] . It remains to be determined if interference with any of these known regulatory proteins is responsible for the dominant-positive effect.
BCR-induced activation of the ERK and JNK MAPK pathways is impaired in Btk-deficient DT40 cells, but p38 MAPK activation is unaffected [ 9].
Previous studies have implicated Syk in BCR-induced apoptosis in other cell lines [ 37 38 ] . To examine the putative role of Syk in BCR-induced apoptosis and cell cycle arrest in BCL 1 .3B3, we attempted to alter Syk activity through the expression of mutant forms of Syk.
Btk-deficient B cells are defective in BCR-induced PLCγ2 phosphorylation and calcium mobilization [ 8, 11].