Words similar to bcr-induced

Example sentences for: bcr-induced

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Our data is consistent with that of Fluckiger et al [ 8], who proposed that Btk controls BCR-induced calcium signaling by regulating PLCγ2 activation, IP3 levels and calcium store depletion.
BCR-induced interaction between Cbl and Syk increases the susceptibility of Syk to proteolysis [ 55 ] , possibly through enhancement of ubiquitination [ 56 ] . Expression of a dominant-negative SHP-1 phosphatase in the mature murine B cell line K46 resulted in an increase in BCR-induced Syk kinase activity as measured by C3b phosphorylation in an ICKA and enhanced BCR-induced Ca 2+fluxes [ 57 ] . It remains to be determined if interference with any of these known regulatory proteins is responsible for the dominant-positive effect.
These data are in agreement with previous reports that document the requirement for PLCγ2 in BCR-induced JNK activation [ 38].
Previous studies have implicated Syk in BCR-induced apoptosis in other cell lines [ 37 38 ] . To examine the putative role of Syk in BCR-induced apoptosis and cell cycle arrest in BCL 1 .3B3, we attempted to alter Syk activity through the expression of mutant forms of Syk.
These proteins are unlikely to include Lyn or Syk, the two PTKs that are primarily responsible for the BCR-induced tyrosine phosphorylation pattern seen in DT40 whole cell lysates [ 14], since we were unable to detect phosphorylation of Lyn and Syk following specific immunoprecipitations (data not shown).