Example sentences for: bcr-induced

How can you use “bcr-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Previous studies have identified apoptosis and cell cycle arrest as mechanisms of BCR-induced growth arrest in BCL 1 .3B3 cells [ 19 ] . The studies presented here have demonstrated that stimulation of the BCR resulted in the rapid and transient activation of the non-receptor tyrosine kinase, Syk.

  • Biochemical studies of Btk-deficient B cells have shown Btk to be necessary for BCR-induced phospholipase C-γ2 (PLCγ2) phosphorylation, calcium mobilization, extracellular signal-regulated kinase (ERK) and c-Jun NH 2 -terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation, NF-κB activation and apoptosis [ 7, 8, 9, 10, 11, 12].

  • The mechanism by which 4-HT activates Btk:ER is not known, but may be different to the mechanism of BCR-induced activation, since the two stimuli induce phosphorylation on different sites.

  • This was not an artefact of the ER domain, since non-tagged kinase inactive Btk could also restore BCR-induced calcium flux (data not shown).

  • This is consistent with reports that PLCγ2 is necessary for BCR-induced apoptosis [ 37].


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