Words similar to bcr-induced

Example sentences for: bcr-induced

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BCR-induced activation of the ERK and JNK MAPK pathways is impaired in Btk-deficient DT40 cells, but p38 MAPK activation is unaffected [ 9].
In particular, we have found that Btk-deficient DT40 cells reconstituted with Txk, an atypical Tec family PTK, fail to undergo BCR-induced JNK activation (Tomlinson and Johnston, unpublished data) and apoptosis [ 13], but ERK activation is relatively normal [ 13].
Our data is consistent with that of Fluckiger et al [ 8], who proposed that Btk controls BCR-induced calcium signaling by regulating PLCγ2 activation, IP3 levels and calcium store depletion.
Previous studies have implicated Syk in BCR-induced apoptosis in other cell lines [ 37 38 ] . To examine the putative role of Syk in BCR-induced apoptosis and cell cycle arrest in BCL 1 .3B3, we attempted to alter Syk activity through the expression of mutant forms of Syk.
This was not an artefact of the ER domain, since non-tagged kinase inactive Btk could also restore BCR-induced calcium flux (data not shown).