Words similar to bcr-induced

Example sentences for: bcr-induced

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Syk has also been implicated in BCR-induced apoptosis found in the chicken B lymphoma line, DT40 [ 38 ] . To determine the role of Syk kinase activation in the apoptotic response in BCL 1 .3B3, overexpression of a mutant form of Syk was used in an effort to alter the level of Syk activation following BCR engagement.
The mechanism by which 4-HT activates Btk:ER is not known, but may be different to the mechanism of BCR-induced activation, since the two stimuli induce phosphorylation on different sites.
Btk-deficient B cells are defective in BCR-induced PLCγ2 phosphorylation and calcium mobilization [ 8, 11].
Previous studies have implicated Syk in BCR-induced apoptosis in other cell lines [ 37 38 ] . To examine the putative role of Syk in BCR-induced apoptosis and cell cycle arrest in BCL 1 .3B3, we attempted to alter Syk activity through the expression of mutant forms of Syk.
This was not an artefact of the ER domain, since non-tagged kinase inactive Btk could also restore BCR-induced calcium flux (data not shown).