Words similar to bcr-induced

Example sentences for: bcr-induced

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This was not an artefact of the ER domain, since non-tagged kinase inactive Btk could also restore BCR-induced calcium flux (data not shown).
Biochemical studies of Btk-deficient B cells have shown Btk to be necessary for BCR-induced phospholipase C-γ2 (PLCγ2) phosphorylation, calcium mobilization, extracellular signal-regulated kinase (ERK) and c-Jun NH 2 -terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation, NF-κB activation and apoptosis [ 7, 8, 9, 10, 11, 12].
BCR-induced interaction between Cbl and Syk increases the susceptibility of Syk to proteolysis [ 55 ] , possibly through enhancement of ubiquitination [ 56 ] . Expression of a dominant-negative SHP-1 phosphatase in the mature murine B cell line K46 resulted in an increase in BCR-induced Syk kinase activity as measured by C3b phosphorylation in an ICKA and enhanced BCR-induced Ca 2+fluxes [ 57 ] . It remains to be determined if interference with any of these known regulatory proteins is responsible for the dominant-positive effect.
This pathway is controlled by the small GTP-binding protein Rac1 and in DT40 cells Rac1 is essential for BCR-induced JNK activation [ 38].
These proteins are unlikely to include Lyn or Syk, the two PTKs that are primarily responsible for the BCR-induced tyrosine phosphorylation pattern seen in DT40 whole cell lysates [ 14], since we were unable to detect phosphorylation of Lyn and Syk following specific immunoprecipitations (data not shown).