Words similar to bcr-mediated

Example sentences for: bcr-mediated

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The formation of large protein complexes associated with the membrane receptor through specific protein-protein interactions appears to be an early step in BCR-mediated signal transduction.
In contrast, BCR-mediated activation of Lyn kinase was largely maintained [ 37 38 ] . The Syk-dependent signaling pathway appears to be facilitated by the adaptor molecule BLNK (also known as SLP-65 and BASH) [ 39 40 41 ] . Syk can induce the phosphorylation of BLNK in co-transfection experiments [ 42 ] , which may be important for the recruitment of other Syk substrates like PLCγ2 through a scaffolding function [ 42 ] . BLNK function is necessary for signal transduction since no Ca 2+flux or PLCγ2 phosphorylation is observed in response to BCR engagement in BLNK-deficient DT40 cells [ 43 ] .
BCR-mediated tyrosine kinase activation is thought to be involved in the signal transduction cascades that give rise to these changes in cell growth and viability [ 19 ] . To determine if BCR engagement under these conditions leads to Syk kinase activation, increasing amounts of anti-IgM were added to cultured BCL 1 .3B3 cells.
AMH and JL helped to define the effects of BCR-mediated signal transduction on the growth and apoptosis of BCL 1 .3B3.
BCR-mediated apoptosis was preceded by an increase in Syk kinase activity in BCL 1 .3B3.