Words similar to bcr-abl

Example sentences for: bcr-abl

How can you use “bcr-abl” in a sentence? Here are some example sentences to help you improve your vocabulary:

This approach is best exemplified by Gleevec and BCR-ABL fusion kinase in chronic myelogenous leukemia [ 4 ] .
It is also possible that EGFR amplification itself plays a role in acquired resistance, since imatinib-resistant clones have been shown to lack resistance mutations but contain amplified copies of BCR-ABL [11,28].
Indeed, about three years after the recognition of imatinib resistance mutations in BCR-ABL-positive CML, new drugs are now in clinical trials that are potent inhibitors of imatinib-resistant BCR-ABL mutants [13,14].
Since the effect of Gleevec is mediated through inhibiting BCR-ABL tyrosine kinase, c-kit, and PDGF receptors, we are interested in the potential target for Gleevec effect in the lung cancer cells.
Recently, new small-molecule inhibitors have been identified that retain activity against the majority of imatinib-resistant BCR-ABL mutants.