Words similar to bcr-abl

Example sentences for: bcr-abl

How can you use “bcr-abl” in a sentence? Here are some example sentences to help you improve your vocabulary:

Gleevec was designed to inhibit the BCR-ABL tyrosine kinase, and it cross-reacts with c-kit and PDGFR [ 5 ] . In non-small cell lung cancer, BCR-ABL expression has never been reported, and it is unlikely that BCR-ABL fusion protein plays any role in lung cancer.
Imatinib (Gleevec), a 2-phenylaminopyrimidine, is a competitive inhibitor of ATP binding to the ABL kinase, thereby inhibiting the constitutively activated BCR-ABL tyrosine kinase.
Recently, new small-molecule inhibitors have been identified that retain activity against the majority of imatinib-resistant BCR-ABL mutants.
Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.
This approach is best exemplified by Gleevec and BCR-ABL fusion kinase in chronic myelogenous leukemia [ 4 ] .