Words similar to bcr-abl

Example sentences for: bcr-abl

How can you use “bcr-abl” in a sentence? Here are some example sentences to help you improve your vocabulary:

The paradigm for tyrosine kinase inhibition as treatment for cancer using small-molecule inhibitors was first established in the context of chronic myelogenous leukemia (CML) associated with the BCR-ABL gene rearrangement [1].
Imatinib (Gleevec), a 2-phenylaminopyrimidine, is a competitive inhibitor of ATP binding to the ABL kinase, thereby inhibiting the constitutively activated BCR-ABL tyrosine kinase.
This approach is best exemplified by Gleevec and BCR-ABL fusion kinase in chronic myelogenous leukemia [ 4 ] .
Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.
Since the effect of Gleevec is mediated through inhibiting BCR-ABL tyrosine kinase, c-kit, and PDGF receptors, we are interested in the potential target for Gleevec effect in the lung cancer cells.