Example sentences for: bcr-abl

How can you use “bcr-abl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Recently, new small-molecule inhibitors have been identified that retain activity against the majority of imatinib-resistant BCR-ABL mutants.

  • Gleevec (also known as STI571, Imatinib from Novartis Pharmaceutical Inc.), a recently FDA approved drug for chronic myelogenous leukemia, is an ATP analogue, and it competitively binds to and inhibits BCR-ABL tyrosine kinase, resulted from the chromosomal translocation t(9; 22).

  • This approach is best exemplified by Gleevec and BCR-ABL fusion kinase in chronic myelogenous leukemia [ 4 ] .

  • Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.

  • Although there are many potential mechanisms for development of clinical resistance, most cases of imatinib-resistant CML are due to point mutations in the BCR-ABL kinase domain itself, including T315I [10,11].


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