Words similar to bcr-abl

Example sentences for: bcr-abl

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Efforts to identify alternative mechanisms for resistance may be guided by experience with imatinib resistance in the context of BCR-ABL, and should include full-length sequencing of EGFR to identify other resistance mutations, and analysis for evidence of gene amplification, as well as investigation of other well-characterized mechanisms of drug resistance such as drug efflux or increased drug metabolism.
Gleevec (also known as STI571, Imatinib from Novartis Pharmaceutical Inc.), a recently FDA approved drug for chronic myelogenous leukemia, is an ATP analogue, and it competitively binds to and inhibits BCR-ABL tyrosine kinase, resulted from the chromosomal translocation t(9; 22).
The paradigm for tyrosine kinase inhibition as treatment for cancer using small-molecule inhibitors was first established in the context of chronic myelogenous leukemia (CML) associated with the BCR-ABL gene rearrangement [1].
It is also possible that EGFR amplification itself plays a role in acquired resistance, since imatinib-resistant clones have been shown to lack resistance mutations but contain amplified copies of BCR-ABL [11,28].
Gleevec was designed to inhibit the BCR-ABL tyrosine kinase, and it cross-reacts with c-kit and PDGFR [ 5 ] . In non-small cell lung cancer, BCR-ABL expression has never been reported, and it is unlikely that BCR-ABL fusion protein plays any role in lung cancer.