Words similar to anaphylactic
Example sentences for: anaphylactic
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Thus, some of us recently showed that administration of two self peptides that can induce EAE, myelin proteolipid protein peptide 139 to 151 (PLP139-151) or myelin oligodendrocyte glycoprotein peptide 35-55 (MOG35-55), can result in severe anaphylactic reactions [ 14 ] . This result clearly indicated that severe allergic reactions to self peptides can occur in mice that have been induced to express pathology (i.e.
[ 14 ] is whether the influence of thymic expression of the self peptide on the propensity to develop anaphylactic reactivity differs in the EAE and NOD T1DM models.
Therefore, because of the risk of induction of anaphylactic sensitization, extreme caution needs to be used in developing any type of antigen-specific immunosuppressive therapy for the prevention or treatment of T1DM.
It should be emphasized that NOD mice have a partial defect in thymic negative selection [ 25 26 ] , a defect in FcγRIIB (that can negatively regulate anaphylactic reactions [ 27 28 ] ), and perhaps other genetic polymorphisms that may result in immunological hyperresponsiveness.
As a result, it has not yet been demonstrated that anaphylactic reactions can develop to self peptides that are expressed in the thymus.