Example sentences for: anaphase-promoting

How can you use “anaphase-promoting” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The histone genes repressed in M/G1 were upregulated in S. In G2 and M, CLB1 (G2/M-specific cyclin involved in mitotic induction), CDC5 (mitotic DNA replication) and CLB2 (G2/M-specific cyclin involved in mitotic induction) were selected as upregulated, in phase M CDC20 (cyclin degradation, part of the anaphase-promoting complex).

  • Based on studies involving compounds that alter microtubular kinetics and induce both cell-cycle delay and aneuploidy, several groups have proposed that temporal perturbations during mammalian oocyte maturation (OM) predispose oocytes to aneuploidy [ 3 4 5 6 ] . In addition to faulty microtubule kinetics, perturbations during OM may also stem from abnormal function of centrosomes, kinetochores, spindle checkpoints proteins, the anaphase-promoting complex (APC), the securin-separin-cohesion complex proteins, and the proteasome [ 7 ] .

  • The MATs are predicated upon the coordinated activities of the spindle checkpoint [ 16 17 ] , the anaphase-promoting complex (APC) or cyclosome [ 18 19 ] , the proteasome [ 20 21 ] , and the cohesion-complex proteins involved with chromosome cohesion and separation [ 22 23 24 ] . Alterations in the temporal sequence of these coordinated activities may potentially predispose cells to faulty chromosome segregation.

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