Words similar to anaphylaxis
Example sentences for: anaphylaxis
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Taken together, these findings suggest that IgG1 antibodies contribute importantly to the development of anaphylaxis in both of these models.
On the other hand, as might be predicted, PD peptides induced a less robust IgG1 response (Figure 2) and also a lower incidence and severity of anaphylaxis (see Table 1and Figure 1) when injected into NOD mice than did G7 peptides.
By contrast, mice that had been immunized with B:9-23 peptide at 10 or 100 μg/dose exhibited a robust and dose-dependent IgG1 antibody response to the peptide [ 15 ] . Thus, in both B:9-23 peptide-associated anaphylaxis (Liu et al . [ 15 ] ) and GAD65 peptide-associated anaphylaxis (our study), anti-peptide IgG1 antibodies contribute to the response.
Indeed, Liu et al . [ 15 ] found that, in NOD mice that had been immunized with peptide B:9-23, treatment with both anti FcγRII/RIII and anti-IgE monoclonal antibodies was required to prevent anaphylaxis upon challenge with the peptide.
In addition to the classical signs of anaphylaxis, such as reddening of the skin, prostration and respiratory impairment, the mice underwent a dramatic drop in body temperature (Fig.
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