Example sentences for: ais

How can you use “ais” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Shown are the 2862 transcripts that distinguish between normal genital skin fibroblasts and gonadal fibroblasts from 46, XY female AIS patients, and between proliferating and confluent fibroblasts.

  • No differences in transcript levels could be discerned between DHT treated and control cells in either normal foreskin fibroblasts or fibroblasts from AIS affected 46, XY females.

  • Several genes expressed specifically in the normal male foreskin fibroblasts have been previously implicated in male genital development, including HOXA13 , the T-box genes, BMP4 and DWnt2 . Mutations in HOXA13 can cause distal limb and urogenital-tract malformations such as male hypospadias in hand-foot-genital syndrome [ 21 ] . T-box genes ( TBX ) are essential early regulators of limb development and also appear to be involved in male genital development [ 22 23 ] . Mutations in TBX3 cause the ulnar-mammary syndrome characterized by limb, apocrine, and genital developmental abnormalities [ 23 ] . Expression of T-box genes 2, 3, and 5 was significantly higher in normal male foreskin fibroblasts than in AIS genital fibroblasts.

  • We found striking differences in the gene expression profiles of genital fibroblasts cultured from normal and AIS patients, but no transcriptional response to androgen was detectable in any of the cultured genital fibroblasts.

  • HOXA13 was expressed at high levels in normal male foreskin fibroblasts and at low levels in all AIS and extragenital fibroblasts (Figure 2).

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