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Example sentences for: ais

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HOXA13 was expressed at high levels in normal male foreskin fibroblasts and at low levels in all AIS and extragenital fibroblasts (Figure 2).
Shown are the 2862 transcripts that distinguish between normal genital skin fibroblasts and gonadal fibroblasts from 46, XY female AIS patients, and between proliferating and confluent fibroblasts.
Development of the male genitalia is largely controlled by cells in the urogenital mesenchyme that express androgen receptors (AR) [ 1 2 ] . Germline mutations of the AR gene produce a spectrum of developmental abnormalities in 46,XY individuals ranging from infertility or mild hypospadias to complete feminization, which are collectively referred to as the androgen insensitivity syndrome (AIS).
We found consistent, characteristic differences in baseline gene expression patterns between genital skin fibroblasts from normal males and 46,XY female patients with AIS.
We found striking differences in the gene expression profiles of genital fibroblasts cultured from normal and AIS patients, but no transcriptional response to androgen was detectable in any of the cultured genital fibroblasts.