Words similar to ais
Example sentences for: ais
How can you use “ais” in a sentence? Here are some example sentences to help you improve your vocabulary:
We used the SAM procedure [ 6 ] to identify genes with statistically significant differences in baseline expression levels between normal and AIS genital fibroblasts.
Development of the male genitalia is largely controlled by cells in the urogenital mesenchyme that express androgen receptors (AR) [ 1 2 ] . Germline mutations of the AR gene produce a spectrum of developmental abnormalities in 46,XY individuals ranging from infertility or mild hypospadias to complete feminization, which are collectively referred to as the androgen insensitivity syndrome (AIS).
For instance, transcripts encoding homeobox A13 protein (HOXA13) and T-box proteins (TBX) showed striking differences in their expression levels between the 'male genital' and 'AIS/extragenital' fibroblasts.
As cultured genital fibroblasts originate from the urogenital mesenchyme and retain expression of the AR in vitro , we compared gene-expression patterns in cultured genital fibroblasts from normal 46,XY males and from 46,XY females with severe or complete AIS, using DNA microarrays representing 32,968 distinct human genes.
Reference mRNA contained equal mixtures of fibroblast mRNA (pooled from confluent and proliferating cultures of normal and AIS genital skin fibroblasts) and a 'common reference' of mRNAs isolated from 11 different proliferating cultured tumor cell lines that we have described previously [ 33 ] .