Words similar to ais
Example sentences for: ais
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Shown are the 2862 transcripts that distinguish between normal genital skin fibroblasts and gonadal fibroblasts from 46, XY female AIS patients, and between proliferating and confluent fibroblasts.
Development of the male genitalia is largely controlled by cells in the urogenital mesenchyme that express androgen receptors (AR) [ 1 2 ] . Germline mutations of the AR gene produce a spectrum of developmental abnormalities in 46,XY individuals ranging from infertility or mild hypospadias to complete feminization, which are collectively referred to as the androgen insensitivity syndrome (AIS).
HOXA13 was expressed at high levels in normal male foreskin fibroblasts and at low levels in all AIS and extragenital fibroblasts (Figure 2).
No differences in transcript levels could be discerned between DHT treated and control cells in either normal foreskin fibroblasts or fibroblasts from AIS affected 46, XY females.
The SAM procedure computes a two-sample T-statistic (for example for normal vs AIS cell lines) for the normalized log ratios of gene-expression levels for each gene.
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