Example sentences for: ais

How can you use “ais” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We used the SAM procedure [ 6 ] to identify genes with statistically significant differences in baseline expression levels between normal and AIS genital fibroblasts.

  • Development of the male genitalia is largely controlled by cells in the urogenital mesenchyme that express androgen receptors (AR) [ 1 2 ] . Germline mutations of the AR gene produce a spectrum of developmental abnormalities in 46,XY individuals ranging from infertility or mild hypospadias to complete feminization, which are collectively referred to as the androgen insensitivity syndrome (AIS).

  • For instance, transcripts encoding homeobox A13 protein (HOXA13) and T-box proteins (TBX) showed striking differences in their expression levels between the 'male genital' and 'AIS/extragenital' fibroblasts.

  • As cultured genital fibroblasts originate from the urogenital mesenchyme and retain expression of the AR in vitro , we compared gene-expression patterns in cultured genital fibroblasts from normal 46,XY males and from 46,XY females with severe or complete AIS, using DNA microarrays representing 32,968 distinct human genes.

  • Reference mRNA contained equal mixtures of fibroblast mRNA (pooled from confluent and proliferating cultures of normal and AIS genital skin fibroblasts) and a 'common reference' of mRNAs isolated from 11 different proliferating cultured tumor cell lines that we have described previously [ 33 ] .


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