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Example sentences for: ais

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No differences in transcript levels could be discerned between DHT treated and control cells in either normal foreskin fibroblasts or fibroblasts from AIS affected 46, XY females.
Notably, the two mosaic AIS cell lines ARD364 and ARD465 showed gene-expression patterns that most resembled normal male foreskin (Figure 2).
We then identified 404 unique transcripts (represented by 487 total cDNAs) with significant differences in expression levels between normal and AIS genital fibroblasts using the significance analysis of microarrays (SAM)-procedure [ 6 ] , with a false discovery rate of less than 0.92% (percent of genes identified by chance alone).
Reference mRNA contained equal mixtures of fibroblast mRNA (pooled from confluent and proliferating cultures of normal and AIS genital skin fibroblasts) and a 'common reference' of mRNAs isolated from 11 different proliferating cultured tumor cell lines that we have described previously [ 33 ] .
Our data suggest that in addition to androgen-independent positional influences on fibroblast phenotypes, the AR is originally involved in establishing stable and reproducible patterns of gene expression in stromal cells during genital differentiation, which are reflected in the differences in global gene-expression patterns between fibroblasts cultured from the genital skin of normal individuals and females affected by AIS.