Words similar to ais-derived

Example sentences for: ais-derived

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However, we were unable to detect any significant changes in gene-expression patterns in cultured, AR-expressing genital fibroblasts or in AIS-derived fibroblasts in response to androgens.
Many of these differences between normal and AIS-derived fibroblasts were also observed in gonadal fibroblasts, suggesting that these differences are not purely due to differences in the anatomical site of origin of the fibroblasts.
et al . found significantly different baseline expression levels of insulin-like growth factor (IGF) and insulin-like growth factor binding protein (IGFBP) between normal and AIS-derived genital skin fibroblasts, and could not detect changes in transcript levels in response to androgen treatment [ 29 ] . In normal genital fibroblasts, androgen-responsive reporter genes can only be activated by expression of co-transfected AR in the presence of ligand [ 30 ] . Therefore, endogenous AR expression itself may be insufficient in genital skin fibroblasts to elicit a transcriptional response.
Unsupervised hierarchical clustering did not disclose any obvious differences in gene-expression patterns between DHT-treated and ethanol-treated fibroblasts, either in normal controls or in AIS-derived cell lines.
Hierarchical cluster analysis of these experiments clearly showed the distinct differences in transcriptional profiles between AIS-derived and normal male fibroblasts and between proliferating and normal fibroblasts (Figure 3).