Example sentences for: ais-derived

How can you use “ais-derived” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For example, cadherin 13 ( CDH13 ), versican ( CSPG2 ), collagen 8A1 ( COL8A1 ), collagen 12A1 ( COL12A1 ), P4HA2 (encoding a procollagen-modifying enzyme) all showed relatively low expression in the genital skin fibroblasts of normal males, whereas tenascin XB ( TNXB ), nidogen 2 ( NID2 ), laminins ( LAMA3 , LAMA4 ) and tissue inhibitor of metalloproteinase 1 ( TIMP1 ) all showed relatively high expression levels compared to AIS-derived fibroblasts (Figure 2).

  • Many of these differences between normal and AIS-derived fibroblasts were also observed in gonadal fibroblasts, suggesting that these differences are not purely due to differences in the anatomical site of origin of the fibroblasts.

  • However, we were unable to detect any significant changes in gene-expression patterns in cultured, AR-expressing genital fibroblasts or in AIS-derived fibroblasts in response to androgens.

  • et al . found significantly different baseline expression levels of insulin-like growth factor (IGF) and insulin-like growth factor binding protein (IGFBP) between normal and AIS-derived genital skin fibroblasts, and could not detect changes in transcript levels in response to androgen treatment [ 29 ] . In normal genital fibroblasts, androgen-responsive reporter genes can only be activated by expression of co-transfected AR in the presence of ligand [ 30 ] . Therefore, endogenous AR expression itself may be insufficient in genital skin fibroblasts to elicit a transcriptional response.

  • On the right, the regions of the cluster diagram are indicated which differentiate between normal and AIS-derived fibroblasts, and proliferating and confluent cells, respectively.


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