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Example sentences for: ais-affected
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In contrast, SAM analysis identified 1,664 transcripts that differed significantly between proliferating and confluent cells, and 1,232 transcripts that differed between fibroblasts derived from AIS-affected individuals and normal male foreskin.
The ARD364 and ARD465 lines express wild-type AR and were derived from individuals who were mosaics for wild-type AR and AR with a premature stop codon [ 7 ] . Hierarchical cluster analysis, based on the expression of 472 of the 487 previously identified transcripts with measurable expression across at least 80% of 24 experiments, separated the fibroblasts into those with gene-expression patterns resembling normal male foreskin fibroblasts and a second group with an expression pattern more similar to labial skin fibroblasts from AIS-affected individuals (Figure 2).
These female AIS-affected individuals are thought to have acquired their AR gene mutations post-zygotically [ 12 ] . ARD364, which showed AR protein expression and binding in the range of normal male foreskin fibroblasts ( [ 7 ] and see Table 1), despite its origin from anatomically female genitalia, had a gene-expression pattern indistinguishable from foreskin fibroblasts of normal males (Figure 2).
The analysis was based on 2,862 transcripts that differed significantly between proliferating and confluent cells and between fibroblasts derived from AIS-affected individuals and normal male foreskin, respectively, as identified by SAM analysis of the treatment series.
Comparison of expression patterns in genital fibroblasts from normal and AIS-affected individuals, and fibroblasts from extragenital sites, offers possible insights into the programs that underlie genital development.
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