Words similar to ais-affected
Example sentences for: ais-affected
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Comparison of gene-expression patterns in genital fibroblasts from normal and AIS-affected individuals, and in fibroblasts from extragenital sites, may offer clues to the programs that underlie external genital development.
The analysis was based on 2,862 transcripts that differed significantly between proliferating and confluent cells and between fibroblasts derived from AIS-affected individuals and normal male foreskin, respectively, as identified by SAM analysis of the treatment series.
We have previously used a similar approach to delineate the transcriptional programs activated in prostate cancer cells in response to androgen [ 9 ] . We had hoped that comparison of transcriptional responses of normal fibroblasts to those from AIS-affected individuals with varying degrees of genital ambiguity would provide still further insights into androgen's role in genital morphogenesis.
Comparison of expression patterns in genital fibroblasts from normal and AIS-affected individuals, and fibroblasts from extragenital sites, offers possible insights into the programs that underlie genital development.
The ARD364 and ARD465 lines express wild-type AR and were derived from individuals who were mosaics for wild-type AR and AR with a premature stop codon [ 7 ] . Hierarchical cluster analysis, based on the expression of 472 of the 487 previously identified transcripts with measurable expression across at least 80% of 24 experiments, separated the fibroblasts into those with gene-expression patterns resembling normal male foreskin fibroblasts and a second group with an expression pattern more similar to labial skin fibroblasts from AIS-affected individuals (Figure 2).
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