Words similar to aggregating
Example sentences for: aggregating
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Aggrecan and versican are aggregating proteoglycans that are key constituents found in the extracellular matrix [ 41 ] . Both proteoglycans contain amino-terminal hyaluronic acid-binding regions, central core glycosaminoglycan attachment domains, and carboxyl-terminal domains containing EGF-like modules (one in aggrecan and two in versican), C-type lectin like modules and complement regulatory protein-like modules [ 49 50 ] . Fibulin-1 exhibits calcium-dependent binding to the carboxyl-terminal domain of aggrecan and versican [ 41 ] . The binding site of aggrecan to fibulin-1 maps to the type II EGF-like modules 8-9 and the carboxyl-terminal domain of fibulin-1 [ 41 ] . The binding site of versican to fibulin-1 maps to the type II EGF-like modules 2-8 of fibulin-1 [ 41 ] .
ES-cell derived embryos were generated by aggregating clumps of around twenty ES cells with individual eight cell embryos or four cell embryos that had been made tetraploid by electrofusion as described previously [ 7 9 23 ] . ES cell:embryo aggregates were cultured overnight and those that formed blastocysts were transferred to the uteri of psuedo-pregnant females surrogate mothers.
We next addressed whether embryos could be generated solely from F3 Hprt negative ES cells by aggregating these cells with tetraploid CD-1 embryos and allowing them to develop in utero until day 13 of gestation (El 3).
Methods of assessing the reliability of observations, techniques for transforming very large amounts of qualitative data, and methods for aggregating qualitative data or findings from several sites have been developed.
Nagy et al demonstrated that embryos and mice could be derived solely from R1 ES cells by aggregating them with tetraploid embryos [ 7 8 ] . Although we were able to repeat these data using R1 ES cells we were unable to generate midgestation embryos from E14TG2a-derived strains of hprt negative ES cell lines using the same approach [ 9 10 11 ] . We believed it was unlikely that Hprt itself was required to generate ES cell-derived embryos because hprt knockout mice are viable and fertile [ 12 ] . E14TG2a-derived ES cell lines contain a large spontaneous deletion encompassing 55 kb of the hprt locus [ 13 ] . Therefore, it seemed possible that sequences within this region were necessary to maintain ES cell pluripotency.
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