Example sentences for: aggrecan

How can you use “aggrecan” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Chondrocytic differentiation was confirmed by the gene expression of collagen II and aggrecan , two components of extracellular matrix selectively expressed by chondrocytes, using RT-PCR (Figure 2B).

  • The Unigene (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=unigene) accession numbers for the gene products discussed in this paper are aggrecan (Hs.

  • SMAD4 contributes to transforming growth factor-β (TGF-β)-dependent transcription of the alpha 2(I)-collagen (COL1A2) [ 35] and aggrecan [ 36] genes.

  • Aggrecan and versican are aggregating proteoglycans that are key constituents found in the extracellular matrix [ 41 ] . Both proteoglycans contain amino-terminal hyaluronic acid-binding regions, central core glycosaminoglycan attachment domains, and carboxyl-terminal domains containing EGF-like modules (one in aggrecan and two in versican), C-type lectin like modules and complement regulatory protein-like modules [ 49 50 ] . Fibulin-1 exhibits calcium-dependent binding to the carboxyl-terminal domain of aggrecan and versican [ 41 ] . The binding site of aggrecan to fibulin-1 maps to the type II EGF-like modules 8-9 and the carboxyl-terminal domain of fibulin-1 [ 41 ] . The binding site of versican to fibulin-1 maps to the type II EGF-like modules 2-8 of fibulin-1 [ 41 ] .

  • Fibulin-1 has been reported to interact with such extracellular matrix proteins as fibronectin, laminin, nidogen, aggrecan and versican [ 39 40 41 42 ] . Fibronectin is a glycoprotein found as multimers in insoluble form in the extracellular matrix.


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