Words similar to aggrecanase

Example sentences for: aggrecanase

How can you use “aggrecanase” in a sentence? Here are some example sentences to help you improve your vocabulary:

For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.