Words similar to aggregation
Example sentences for: aggregation
How can you use “aggregation” in a sentence? Here are some example sentences to help you improve your vocabulary:
To examine at the molecular level the reason for the earlier aggregation of ifkA null cells, the mRNA levels were examined for two proteins involved in the cAMP pulsing mechanism of aggregation and chemotaxis.
They noted that both prion proteins contain an oligopeptide repeat QGGYQ in close proximity to Q/N-rich sequences and examined the functional significance of the repeats for aggregation and maintenance of the prions.
Recent studies on neurodegenerative diseases, including Parkinson's, Alzheimer's and prion diseases, suggest that it is not the long fibrils that produce toxicity and kill neurons, rather, it is the oligomeric aggregation intermediates that produce toxicity [ 54 55 ] . Interestingly, interactions between biomembranes and toxic proteins produce a dual effect of both promoting oligomeric aggregation of the proteins and membrane damage [ 56 57 58 59 ] , suggesting that one possible toxicity of oligomeric aggregates is mediated through damaging membranes.
SOD1 aggregates have been widely observed in mutant SOD1 transgenic mice and in human ALS caused by SOD1 mutations [ 11 14 35 36 ] . In cultured cells, mutant SOD1 forms high molecular weight aggregates when the cells are stressed by high mutant protein expression [ 51 ] , proteosome inhibition [ 52 ] and serum withdraw [ 27 ] . The role of mutant SOD1 aggregation, however, remains unclear.
This is based on aggregation assays showing different time courses, additive dose response relationships, and differential co-localization of the dystrophin complex, and on biochemical observations indicating the lack of requirement for MuSK, and the lack of tyrosine-phosphorylation of receptors during LN1 but not agrin induced aggregation [ 1 2 4 ] . The very minimal receptor aggregation seen in agrin deficient mice certainly argues that laminins are not sufficient to trigger receptor aggregation [ 5 ] . More recently we have shown that agrin and LN1 induced aggregates can also be differentiated on the basis of the ultrastructural arrangement of receptors within aggregates [ 6 ] .
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