Words similar to adrenalectomy

Example sentences for: adrenalectomy

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Successful adrenalectomy was verified by visual inspection at the time of sacrifice, as well as by the induction of pituitary proopiomelanocortin (POMC) mRNA levels and the reduction in serum corticosterone levels.
Adrenalectomy led to only minor improvement in impaired glucose tolerance (Fig.
We had previously shown that fasting could regulate hypothalamic gene expression in insulin-deficient mice even though in these mice fasting did not influence plasma leptin or insulin [ 5 ] . Since adrenalectomy blocked the fasting-induced reduction in melanocortin tone in diabetic mice (as it had in euglycemic mice in the first study), these results suggest that effects of fasting on melanocortin tone in diabetic mice may be mediated at least in part by a rise in plasma corticosterone (itself possibly secondary to the reduction in plasma leptin).
In the present study, adrenalectomy and corticosterone implants were used to address the role of elevated corticosterone in mediating the effects of fasting and insulin deficiency on hypothalamic gene expression, resulting in several novel observations.
In the present study, we observed that adrenalectomy did indeed lead to a remarkable enhancement of hypothalamic POMC mRNA tone in mice made obese on a high-fat diet; surprisingly, however, adrenalectomy did not reverse diet-induced obesity.