Example sentences for: adrenalectomy

How can you use “adrenalectomy” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Since adrenalectomy blocked the elevation of AGRP mRNA by fasting and insulin deficiency, elevation of corticosterone would be expected to increase hypothalamic AGRP mRNA, as was indeed observed.

  • We had previously shown that fasting could regulate hypothalamic gene expression in insulin-deficient mice even though in these mice fasting did not influence plasma leptin or insulin [ 5 ] . Since adrenalectomy blocked the fasting-induced reduction in melanocortin tone in diabetic mice (as it had in euglycemic mice in the first study), these results suggest that effects of fasting on melanocortin tone in diabetic mice may be mediated at least in part by a rise in plasma corticosterone (itself possibly secondary to the reduction in plasma leptin).

  • The further elevation in POMC expression observed after adrenalectomy of the obese mice could plausibly be due to elevated leptin combined with decreased glucocorticoids, since glucocorticoids may antagonize the effects leptin [ 30 ] .

  • Adrenalectomy led to only minor improvement in impaired glucose tolerance (Fig.

  • In the present study, adrenalectomy and corticosterone implants were used to address the role of elevated corticosterone in mediating the effects of fasting and insulin deficiency on hypothalamic gene expression, resulting in several novel observations.


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