Example sentences for: adduct

How can you use “adduct” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • No particular protein was identified as a specific target for 4-HNE adduct formation in these studies.

  • There was a dose-dependent increase of 4-HNE protein adduct after H 2 O 2 treatment with a maximal intensity of ~7X control at 2 mM H 2 O 2 (Fig.

  • For example, levels of 4-HNE increased significantly in the vitreous of patients with proliferative vitreoretinopathy compared with controls [ 17 ] . Further, 4-HNE forms a stable adduct with rhodopsin in the photoreceptor, which may interfere with its functions [ 18 ] . 4-HNE even causes cataracts in cultured rat lens [ 19 20 ] . Whether oxidative stress on RPE can cause accumulation of cellular HNE-protein adducts remains unknown.

  • The exceptions are a study in which it was reported that the oxygen radical derived DNA adduct 7,8-dihydro-8-oxoguanosine (8-OH-dG) is present in the islets of diabetic Goto-Kakizaki rats, a model of type 2 diabetes [ 31 ] . Also, after submission of the present study, it was reported that an increased number of 8-OH-dG positive islet cells is observed in pancreata from human type 2 diabetic subjects.

  • The reason for this is that we found high levels of background staining with the anti-8-OH-dG antibodies, which is not unusual when using streptavidin/biotin detection systems in immunohistochemistry [ 39 ] . Unfortunately, secondary antibodies directly linked to a fluorophore or a detection enzyme were not sensitive enough to detect the 8-OH-dG adduct in our hands.

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