Words similar to adducts
Example sentences for: adducts
How can you use “adducts” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our current observation that undetectable levels of MGMT gene expression in >95% of GCTs appears to suggest that the lack of the O(6)-methylguanine-DNA methyltransferase enzyme may direct cells to undergo apoptosis due to failure of repair of DNA adducts formed by alkylating agents.
For example, levels of 4-HNE increased significantly in the vitreous of patients with proliferative vitreoretinopathy compared with controls [ 17 ] . Further, 4-HNE forms a stable adduct with rhodopsin in the photoreceptor, which may interfere with its functions [ 18 ] . 4-HNE even causes cataracts in cultured rat lens [ 19 20 ] . Whether oxidative stress on RPE can cause accumulation of cellular HNE-protein adducts remains unknown.
Such an apoptotic defect could account for the increasing intensity of Ogg1 staining, following accumulated levels of 8-OH-dG adducts with longer duration of diabetes.
However, the nuclear localization of 8-OH-dG [ 32 ] and the increased Ogg1 reported here are consistent with a model in which mitochondrial Ogg1 is up-regulated but nuclear Ogg1 is not, leading to an increase in nuclear but not mitochondrial 8-OH-dG adducts [ 32 ] . Further studies will be required to resolve this issue, but β-cells in type 2 diabetes may well suffer from both nuclear and mitochondrial DNA damage, leading to decreased β-cell function and eventual loss of β-cell mass.
first reported oxidative stress caused by t-butylhydroperoxide or iron/ascorbate could lead to 4-HNE protein adducts in hepatocytes [ 62 ] . Further studies by these researchers attempted to identify the common epitope recognized by the 4-HNE antibodies.
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