Words similar to adducts
Example sentences for: adducts
How can you use “adducts” in a sentence? Here are some example sentences to help you improve your vocabulary:
The standard treatment for advanced-stage cervix cancer has been the combination of radical surgery and radiotherapy [ 36 ] . The utility of cytotoxic chemotherapy in patients with advanced CC has been recognized recently [ 37 ] . Thus, the epigenetic gene silencing of MGMT , although in a small proportion, may serve as indicator of responsiveness to treatment with chemotherapeutic drugs that cause DNA adducts in CC.
MGMT gene encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 33 ] . Epigenetic gene silencing of MGMT confers enhanced sensitivity to alkylating-based chemotherapy, and lack of methylation associates with failure to respond to chemotherapy [ 34 35 ] . On the contrary, all patients that had MGMT promoter methylation were dead within 21 months of initial diagnosis, which predicts a poor prognosis.
However, the nuclear localization of 8-OH-dG [ 32 ] and the increased Ogg1 reported here are consistent with a model in which mitochondrial Ogg1 is up-regulated but nuclear Ogg1 is not, leading to an increase in nuclear but not mitochondrial 8-OH-dG adducts [ 32 ] . Further studies will be required to resolve this issue, but β-cells in type 2 diabetes may well suffer from both nuclear and mitochondrial DNA damage, leading to decreased β-cell function and eventual loss of β-cell mass.
ERK activation and 4-HNE protein adducts formation as a result of oxidative stress
Such an apoptotic defect could account for the increasing intensity of Ogg1 staining, following accumulated levels of 8-OH-dG adducts with longer duration of diabetes.
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