Words similar to adducts

Example sentences for: adducts

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However, the nuclear localization of 8-OH-dG [ 32 ] and the increased Ogg1 reported here are consistent with a model in which mitochondrial Ogg1 is up-regulated but nuclear Ogg1 is not, leading to an increase in nuclear but not mitochondrial 8-OH-dG adducts [ 32 ] . Further studies will be required to resolve this issue, but β-cells in type 2 diabetes may well suffer from both nuclear and mitochondrial DNA damage, leading to decreased β-cell function and eventual loss of β-cell mass.
It would be of great interest to study the Ogg1 mutant mice to determine whether an increase level of 8-OH-dG adducts predisposes to diabetes.
Subsequent experiments with immunofluorescent staining indicated that 1.5 mM H 2 O 2 treatment of ARPE-19 cells for 4 hours led to the formation of 4-HNE protein adducts both in the cytoplasm and nucleus, presumably as a result of lipid-peroxidation (Fig.
Results from the current study indicate that H 2 O 2 treatment of RPE could lead to the accumulation of 4-HNE protein adducts in the cytoplasm and the nuclei of these cells (Fig.
, leakage of radicals associated with the reduction of oxygen to water during mitochondrial respiration) [ 34 ] . The etiological basis for the formation of abnormally high levels of 8-oxoguanine adducts in oogonia of lambs of undernourished ewes is unknown.