Example sentences for: adducts

How can you use “adducts” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Results from the current study indicate that H 2 O 2 treatment of RPE could lead to the accumulation of 4-HNE protein adducts in the cytoplasm and the nuclei of these cells (Fig.

  • However, the nuclear localization of 8-OH-dG [ 32 ] and the increased Ogg1 reported here are consistent with a model in which mitochondrial Ogg1 is up-regulated but nuclear Ogg1 is not, leading to an increase in nuclear but not mitochondrial 8-OH-dG adducts [ 32 ] . Further studies will be required to resolve this issue, but β-cells in type 2 diabetes may well suffer from both nuclear and mitochondrial DNA damage, leading to decreased β-cell function and eventual loss of β-cell mass.

  • For example, levels of 4-HNE increased significantly in the vitreous of patients with proliferative vitreoretinopathy compared with controls [ 17 ] . Further, 4-HNE forms a stable adduct with rhodopsin in the photoreceptor, which may interfere with its functions [ 18 ] . 4-HNE even causes cataracts in cultured rat lens [ 19 20 ] . Whether oxidative stress on RPE can cause accumulation of cellular HNE-protein adducts remains unknown.

  • Such an apoptotic defect could account for the increasing intensity of Ogg1 staining, following accumulated levels of 8-OH-dG adducts with longer duration of diabetes.

  • However, no specific protein was positively identified [ 63 ] . More recently, the formation of 4-HNE protein adducts was also demonstrated by Western blot analysis from the heart [ 64 ] , the liver [ 65 ] and the kidney [ 66 ] under oxidative stress.

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