Words similar to acidic
Example sentences for: acidic
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The presence of around 6 conserved acidic positions in the majority of the CYTH domains suggests that it coordinates two divalent metal ions.
Surprisingly, the ester moiety of acetylcholine does not seem to interact with the cys-loop of the receptor, as previously suggested by photoaffinity labeling [ 12 ] , but is engaged in similar type of interaction as that observed with the acidic group of HEPES in the AChBP crystal structure [ 6 ] . It is possible that the reactive di-azo group of the photosensitive agonist used in photoaffinity labeling would extend towards the cys-loop, while the conformation of the bound agonist remains in agreement with our model.
While the catalytic domains of these two superfamilies have very different folds, they follow a similar reaction mechanism that is dependent on two Mg 2+ions coordinated by a cluster of acidic residues.
Egloff and colleagues identified seven acidic surface residues on the catalytic face of PP1c γ that are replaced by neutral or basic residues in PP2A [ 25 ] . They suggest the presence of these acidic residues in PP1c γ may explain why casein is a good substrate for PP2A, but not for PP1.
Alternatively, these basic peptides may bind different regions of the holoenzyme component(s) recognized by acidic peptides, or entirely different subunits [ 21 ] .