Words similar to acids
Example sentences for: acids
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Strong acids and volatile organic solvents employed in glassware cleaning must be used in a fume hood or under an exhaust canopy over the work area.
Alignment of this sequence (amino acids 39 to 74) with the central conserved residues of motif I: A--GWEK---E---LK--L------------R--H-D (-- indicating non-conserved residues) shows a good match of identical and conserved amino acid residues: A--GFEK---D---LK--I---------R--H-E.
This modification occurs on a cysteine residue, three residues proximal to the C-terminus with two aliphatic amino acids separating the cysteine from the C-terminus (hence the term CAAX box).
Protein phosphatase 5 has been implicated in the control of cell proliferation, in hormonal signal transduction, and in hsp90 chaperone function [ 3 11 12 13 14 15 16 17 ] . However little is known about the regulation of PP5 or its specific role in these pathways, and only one physiological substrate for PP5 has been identified to date, the apoptosis signaling kinase ASK 1 [ 13 ] . PP5 can be activated by lipid in vitro , and removal of the TPR domain or the C terminus generates an active, lipid insensitive form of the enzyme [ 18 19 20 21 ] . PP5 phosphatase activity is also altered by hCRY2 and a fragment of hsp90 in vitro [ 21 22 ] . These findings suggest that PP5 may be autoinhibited and that the binding of protein partners or lipids to the TPR domain could potentially control PP5 activity in cells, however no reports have yet documented how PP5 is regulated in vivo . The activity of PP5 homologs from cauliflower, T. brucei and P. falciparum is stimulated by polyunsaturated fatty acids in vitro [ 7 8 9 10 ] and removal of the TPR domain from P. falciparum PP5 increases activity to the same extent as lipid treatment [ 8 9 ] . This suggests that the TPR domain plays a similar inhibitory role for all PP5 homologs.
For 10 of the 18 amino acids with more than one codon (Arg, Asn, His, Ile, Leu, Lys, Phe, Pro, Thr, Tyr), the most frequently used codon in D. willistoni differs from that in D. melanogaster . All 10 of these changes in synonymous codon usage involve D. willistoni most frequently using an A- or T-ending (or beginning, for example, Leu) codon with D. melanogaster using a G- or C-ending (or beginning) codon, supporting a trend identified originally using only the Adh coding sequence [ 41].
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