Words similar to zas-c
Example sentences for: zas-c
How can you use “zas-c” in a sentence? Here are some example sentences to help you improve your vocabulary:
We obtained fifty-three KRC/ZAS-N selected sequences and forty-nine KRC/ZAS-C selected sequences.
These data show that the site selection amplification binding assays using both KRC DNA-binding domains were efficient in selecting KRC targets and that KRC/ZAS-C readily formed highly ordered DNA-protein structures.
For example, the KRC/ZAS-C consensus sequence "ATTTTGTGG" matches completely with 6 nucleotides of the RSS nonamer and 3 flanking nucleotides of the human IgH D1, D2, D3 and D4 gene segments [ 35 ] . Furthermore, the MAST search identified KRC-selected motifs near two chromosomal breakpoints: between a t(11:14) translocation of the Ig DH2-2 gene segment and the B cell lymphoma 1 ( BCL-1 ) gene in a mantle cell lymphoma [ 36 ] , and at a t(11:19) translocation of the myeloid lymphoid leukemia ( MLL ) gene and the ENL/MLLT1/LTG19 gene in a T-cell acute lymphoblastic leukemia [ 37 ] . The other hits were derived from loci of cellular genes, pseduogenes, or DNA fragments [ 41 42 43 44 ] . The expression of those genes has not been shown to be regulated by KRC or other family members, therefore, the biological significance of those MAST results is unknown.
Since the RSS heptamer is a palindrome, it is possible for two KRC molecules to bind to an RSS heptamer, with one ZAS-C binding to the top strand and the other ZAS-C binding to the bottom strand.
We had previously shown by methylation interference analysis that KRC/ZAS-C bound specifically to the sequence TGTGG within the context of the canonical RSS heptamer plus the immediately flanking guanine [ 14 ] . Because the pentamer motif for KRC/ZAS-C predicted by MEME completely matched with the empirical results, we conclude that the two pentameric motifs discovered by MEME are likely authentic binding sites for KRC/ZAS-N as well.
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