Words similar to zas

Example sentences for: zas

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In addition, a distant relative Schnurri ( Shn ) has been identified in Drosophila [ 18 19 20 ] . Although little is known about the physiological functions of the mammalian ZAS proteins, Shn has been shown to be an important transcription regulator during embryonic development.
The ZAS domain is a protein structure unique to the ZAS protein family.
The ability of KRC to promote transcription of target genes has been demonstrated for the S100/mts1 gene by binding at the Sb enhancer motif [ 4 ] . Similarly, binding of κB-like motifs by other ZAS proteins has also been implicated in transcriptional regulation [ 1 2 3 17 ] . Considering KRC's target sequences, the κB motif and the RSS, the two binding domains on a single KRC protein could theoretically bring together cis -acting DNA elements for gene regulation, V(D)J recombination, or both.
For example a copy of GGTTT and its complement can form a sequence GG(N 5-6 )CC, fulfilling the minimal DNA binding requirement for the ZAS proteins other than a lack of the 5' guanine [ 25 ] . Similarly, the GT-rich RSS nonamer and the palindromic RSS heptamer can serve as binding sites of KRC.
Each ZAS gene encodes large sequence-specific DNA-binding proteins with Mr >250,000 that contain two widely separated of C 2 H 2 -type zinc finger pairs.