Words similar to zas
Example sentences for: zas
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Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
The cumulative data show that individual ZAS domains bind a κB-like consensus sequence, GGGN (4-5) CC [ 25 ] . However, mouse KRC, αACRYBP1 and mouse MIBP1 have also been shown to bind distinct DNA sequences.
A ZAS domain denotes a composite protein structure consisting of a pair of C 2 H 2
The ability of KRC to promote transcription of target genes has been demonstrated for the S100/mts1 gene by binding at the Sb enhancer motif [ 4 ] . Similarly, binding of κB-like motifs by other ZAS proteins has also been implicated in transcriptional regulation [ 1 2 3 17 ] . Considering KRC's target sequences, the κB motif and the RSS, the two binding domains on a single KRC protein could theoretically bring together cis -acting DNA elements for gene regulation, V(D)J recombination, or both.
Each ZAS gene encodes large sequence-specific DNA-binding proteins with Mr >250,000 that contain two widely separated of C 2 H 2 -type zinc finger pairs.
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