Words similar to zas
Example sentences for: zas
How can you use “zas” in a sentence? Here are some example sentences to help you improve your vocabulary:
On Naxos, you can walk through the pretty villages of the Tragea Valley and the foothills of Mount Zas, admiring Byzantine churches and exploring olive groves at your leisure.
The cumulative data show that individual ZAS domains bind a κB-like consensus sequence, GGGN (4-5) CC [ 25 ] . However, mouse KRC, αACRYBP1 and mouse MIBP1 have also been shown to bind distinct DNA sequences.
Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
This is the first study to evaluate DNA targets of both ZAS domains from a single protein independently.
Smaller protein isoforms with a single zinc finger pair or with no zinc finger pairs can be generated by alternative RNA splicing [ 23 24 ] . The amino acid sequence and relative location of the two zinc finger pairs are highly conserved among ZAS proteins from invertebrate to vertebrate [Reviewed in [ 25 ] ]. Although the zinc finger is a major structural motif involved in protein-nucleic acid interactions and is present in the largest superfamily of transcription factors, few proteins contain separate zinc finger pairs.
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