Words similar to zas
Example sentences for: zas
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Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
The ZAS proteins (with two zinc finger pairs), tramtrack (with one finger pair), and basonuclin (with three finger pairs), constitute a unique class of C 2 H 2 zinc finger transcription factors.
The amino acid residues at position -1, 2, 3 and 6 of the α helix form base contacts with DNA [Reviewed in [ 49 ] ]. The amino acid sequences of the zinc finger pairs among the ZAS proteins are highly conserved [Reviewed in [ 25 ] ]. The conservation of the zinc fingers from invertebrate to vertebrate species and their common DNA binding target sequences suggest that these proteins may play similar physiological roles in diverse organisms.
In addition, a distant relative Schnurri ( Shn ) has been identified in Drosophila [ 18 19 20 ] . Although little is known about the physiological functions of the mammalian ZAS proteins, Shn has been shown to be an important transcription regulator during embryonic development.
Each ZAS gene encodes large sequence-specific DNA-binding proteins with Mr >250,000 that contain two widely separated of C 2 H 2 -type zinc finger pairs.
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