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Example sentences for: zas
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The amino acid residues at position -1, 2, 3 and 6 of the α helix form base contacts with DNA [Reviewed in [ 49 ] ]. The amino acid sequences of the zinc finger pairs among the ZAS proteins are highly conserved [Reviewed in [ 25 ] ]. The conservation of the zinc fingers from invertebrate to vertebrate species and their common DNA binding target sequences suggest that these proteins may play similar physiological roles in diverse organisms.
[Reviewed in [ 26 ] ]. In addition, each ZAS protein contains a sequence similar to the serine stripe present in basonuclin, in which eight serines are located on one side of a putative α-helix [ 13 27 ] .
Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
The ability of KRC to promote transcription of target genes has been demonstrated for the S100/mts1 gene by binding at the Sb enhancer motif [ 4 ] . Similarly, binding of κB-like motifs by other ZAS proteins has also been implicated in transcriptional regulation [ 1 2 3 17 ] . Considering KRC's target sequences, the κB motif and the RSS, the two binding domains on a single KRC protein could theoretically bring together cis -acting DNA elements for gene regulation, V(D)J recombination, or both.
The ZAS proteins (with two zinc finger pairs), tramtrack (with one finger pair), and basonuclin (with three finger pairs), constitute a unique class of C 2 H 2 zinc finger transcription factors.
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