Words similar to zas
Example sentences for: zas
How can you use “zas” in a sentence? Here are some example sentences to help you improve your vocabulary:
The ZAS domain is a protein structure unique to the ZAS protein family.
The amino acid residues at position -1, 2, 3 and 6 of the α helix form base contacts with DNA [Reviewed in [ 49 ] ]. The amino acid sequences of the zinc finger pairs among the ZAS proteins are highly conserved [Reviewed in [ 25 ] ]. The conservation of the zinc fingers from invertebrate to vertebrate species and their common DNA binding target sequences suggest that these proteins may play similar physiological roles in diverse organisms.
The DNA binding specificity of the ZAS-N or ZAS-C domains from several ZAS members have been characterized by electrophoretic mobility shift assays, methylation interference experiments, and DNAse I footprinting experiments.
Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
A ZAS domain denotes a composite protein structure consisting of a pair of C 2 H 2
Loading...