Words similar to zas
Example sentences for: zas
How can you use “zas” in a sentence? Here are some example sentences to help you improve your vocabulary:
Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
In addition, a distant relative Schnurri ( Shn ) has been identified in Drosophila [ 18 19 20 ] . Although little is known about the physiological functions of the mammalian ZAS proteins, Shn has been shown to be an important transcription regulator during embryonic development.
The cumulative data show that individual ZAS domains bind a κB-like consensus sequence, GGGN (4-5) CC [ 25 ] . However, mouse KRC, αACRYBP1 and mouse MIBP1 have also been shown to bind distinct DNA sequences.
A ZAS domain denotes a composite protein structure consisting of a pair of C 2 H 2
The DNA binding specificity of the ZAS-N or ZAS-C domains from several ZAS members have been characterized by electrophoretic mobility shift assays, methylation interference experiments, and DNAse I footprinting experiments.
Loading...