Example sentences for: xenograft

How can you use “xenograft” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The results of cell culture and animal studies have shown that omega 3 polyunsaturated fatty acids (n-3 PUFAs) selectively killed cancer cells in vitro [ 1 ] . Furthermore, n-3 PUFAs incorporated into animal diets have reduced tumor growth rates in vivo [ 2 3 4 ] . The prevailing hypothesis for the reduction in tumor cell growth, in vitro or in vivo , by supplementing the diet with high levels of n-3 PUFAs has been that the incorporation of n-3 PUFAs into cell membranes of the tumor cells increased the susceptibility of the cells for lipid peroxidation and that the products of lipid peroxidation subsequently accumulated to cytostatic or cytotoxic levels [ 2 5 6 7 ] . It has also been reported that supplementing the diet of cancer xenograft bearing mice with n-3 PUFAs could increase the efficacy of edelfosine [ 8 ] , doxorubicin [ 9 ] , mitomycin [ 10 ] , cyclophosphomide and 5-fluorouracil [ 11 ] or irinotecan [ 12 ] against the tumor.

  • Expression datasets of the cell culture and xenograft profiles

  • This conclusion is based on the significant representation of genes associated with cell adhesion and the ECM in both the A549 and the U118 xenograft tumors.

  • In contrast, profiling human genes expressed in a mouse xenograft using a human microarray chip might uncover genes specifically expressed in human cancer cells in xenograft tumors comprised of a mixture of human- and mouse-derived cells [ 4 ] .

  • It can therefore be concluded that, in all but a handful of genes, the numerous significant changes observed in gene expression in the xenograft tumors are due to the cancerous (human) cells and not the surrounding (mouse) host tissue.


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