Words similar to xenograft
Example sentences for: xenograft
How can you use “xenograft” in a sentence? Here are some example sentences to help you improve your vocabulary:
Between the U118 xenograft tumors and cell cultures, 368 genes (387 probe sets) differed significantly (112 genes being higher in tumors and 256 genes being higher in culture), with 29 expected false positives due to chance.
Also of interest are genes that are upregulated in both the cancers, including IGFBP3 (insulin-like growth factor binding protein 3), which, interestingly, is thought to have proapoptotic activities [ 14 ] , and GSN (gelsolin), which has a role in cellular motility and acts as both a regulator and effector of apoptosis [ 15 ] . Further xenograft studies of the type presented here could examine the responses of the host tissue to the tumor (using a mouse microarray chip), as well as temporal changes in gene expression within the developing tumor.
Through multiple molecular analyses we have identified and verified a number of genes whose expression correlates with the metastatic phenotype in this xenograft model.
Of the 112 genes upregulated in U118 xenograft tumors over cultures, 50 were also higher in high-grade glioblastomas over U118 cultures ( p < 0.05).
The results of cell culture and animal studies have shown that omega 3 polyunsaturated fatty acids (n-3 PUFAs) selectively killed cancer cells in vitro [ 1 ] . Furthermore, n-3 PUFAs incorporated into animal diets have reduced tumor growth rates in vivo [ 2 3 4 ] . The prevailing hypothesis for the reduction in tumor cell growth, in vitro or in vivo , by supplementing the diet with high levels of n-3 PUFAs has been that the incorporation of n-3 PUFAs into cell membranes of the tumor cells increased the susceptibility of the cells for lipid peroxidation and that the products of lipid peroxidation subsequently accumulated to cytostatic or cytotoxic levels [ 2 5 6 7 ] . It has also been reported that supplementing the diet of cancer xenograft bearing mice with n-3 PUFAs could increase the efficacy of edelfosine [ 8 ] , doxorubicin [ 9 ] , mitomycin [ 10 ] , cyclophosphomide and 5-fluorouracil [ 11 ] or irinotecan [ 12 ] against the tumor.
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