Words similar to xenobiotic
Example sentences for: xenobiotic
How can you use “xenobiotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Initial results showed that CAR is an apparently constitutive transactivator able to activate gene expression in the absence of exogenously added ligands [ 8 9 ] . The first CAR ligands identified, androstanol and androstenol, are inverse agonists that block this constitutive transactivation [ 10 ] . More recently, it has been found that CAR mediates the characteristic response of a subset of drug metabolizing enzymes to a variety of structurally unrelated foreign compounds [ 11 ] . These xenobiotic activators are referred to as "phenobarbital (PB) - like," based on the prototypic effects of the anti-epileptic agent on drug metabolism [ 12 13 14 ] . The most potent activator of murine CAR is the high affinity agonist ligand TCPOBOP (1,4-bis [2-(3,5-dichloropyridyloxy)]benzene) [ 15 16 ] .
Cyp 1 transcription is activated when cytosolic hydrocarbons activate the Ah receptor which then translocates to the nucleus and heterodimerizes with Arnt, leading to binding to an upstream xenobiotic response element on Cyp 1. Cyps 2-4 are induced through nuclear hormone receptors.
In transient transfections, the rexinoid LG1069 shows different effects on the ability of the xenobiotic receptor to transactivate various response elements.
The results described here also suggest that rexinoids may have modulatory effects on xenobiotic responses, and that such effects may differ for different CAR/RXR target genes.
Overall, these results significantly increase the potential complexity of the response of RXR heterodimers to RXR ligands and suggest a potential modulatory effect of rexinoids on xenobiotic responses.
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