Example sentences for: utr

How can you use “utr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In the case of the HCV RNA, we panned a sequence (AA UUG CCA GGA CGA CCG GGU CCU UUC UUG GAU CAA CCC GCU CAA UGC CUG GAG AUU) predicted to bind to at least one of the proteins comprising the translation complex eukaryotic Initiation Factor 3 (eIF3; [ 11 12 13 14 ] ). Published reports identify the p120 subunit of eIF3 as the one binding to the apical loop of the domain III of HCV 5'UTR, and p170 (also called p160) as binding the stem portion of the domain III.

  • It was recently demonstrated that elements within a 217 nucleotide sequence from the 5'-UTR of the mouse p27 Kip1mRNA is able to mediate cap-independent translation of a reporter gene in NIH3T3 and D6P2T cells [ 28 ] . There is a high level of sequence homology between the mouse and human 5'-UTRs and the major transcriptional start site is also conserved [ 29 ] . Therefore it is likely the 5'-UTR of the human p27 Kip1message is also able to mediate cap-independent translation initiation.

  • Finally, the comparative annotation of UTR sequences awaits the development of methods that accurately predict the non-coding components of gene models.

  • The increase in p27 Kip1is mediated, at least in part, by enhanced synthesis of the protein and corresponds to activation of the p27 Kip1mRNA 5'-untranslated region (UTR) and its ability to mediate cap-independent initiation of translation.

  • The 5' end of the UTR is determined by the site of transcription initiation and several papers have reported putative p27 Kip1transcription initiation sites.


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