Words similar to untransformed
Example sentences for: untransformed
How can you use “untransformed” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, early investigators observed that transfection of untransformed B cells with a plasmid for constitutive expression of IL-6 conferred the tumorigenic phenotype on the cells [ 2 ] . IL-6 is a key factor in myeloma progression and survival [ 3 4 ] , and also in Kaposi's sarcoma, a solid tumor [ 5 ] . In myeloma, the standard therapy for treatment includes prednisone, which acts by inhibiting IL-6 synthesis.
SL-1 induction in p2S cells, an untransformed mouse mammary epithelial cell line, triggered the disappearance of E-cadherin and beta-catenin from cell-cell junctions and reduced the expression of beta-catenin [ 35 ] . Wnt-5a and SL-1 may play similar roles in inhibiting cadherin-mediated cell-adhesion, as Wnt-5a decreases Ca 2+-dependent cell adhesion similar to a dominant negative cadherin [ 11 ] . The regulation of SL-1 by Wnt-5a may be important in developmental processes such as gastrulation where Wnt-5a affects the morphogenetic movement of tissues [ 45 ] .
Analysis of the untransformed data for the final third of the experiment identified a significant decrease in testis size of all of these rats (P < 0.0001, F = 38.
The expression of oncogenes such as ras in untransformed cells stimulates transcription of the p14 Arfgene [ 2].
That a logarithmic transformation gave the most meaningful cluster dendrograms is consistent with the distribution of the untransformed expression data being skewed to the left because the majority of genes have low expression levels.