Words similar to untransformed

Example sentences for: untransformed

How can you use “untransformed” in a sentence? Here are some example sentences to help you improve your vocabulary:

Cell lines do not always respond in the same manner that untransformed cells would in an in vivo context; therefore their use in experimental model systems may not always be appropriate.
SL-1 induction in p2S cells, an untransformed mouse mammary epithelial cell line, triggered the disappearance of E-cadherin and beta-catenin from cell-cell junctions and reduced the expression of beta-catenin [ 35 ] . Wnt-5a and SL-1 may play similar roles in inhibiting cadherin-mediated cell-adhesion, as Wnt-5a decreases Ca 2+-dependent cell adhesion similar to a dominant negative cadherin [ 11 ] . The regulation of SL-1 by Wnt-5a may be important in developmental processes such as gastrulation where Wnt-5a affects the morphogenetic movement of tissues [ 45 ] .
The expression of oncogenes such as ras in untransformed cells stimulates transcription of the p14 Arfgene [ 2].
For example, early investigators observed that transfection of untransformed B cells with a plasmid for constitutive expression of IL-6 conferred the tumorigenic phenotype on the cells [ 2 ] . IL-6 is a key factor in myeloma progression and survival [ 3 4 ] , and also in Kaposi's sarcoma, a solid tumor [ 5 ] . In myeloma, the standard therapy for treatment includes prednisone, which acts by inhibiting IL-6 synthesis.
Analysis of the untransformed data identified a significant overall decrease in testis size of all of these rats over the final third of the experiment (P < 0.0001, F = 83.