Words similar to ubiquitin-independent

Example sentences for: ubiquitin-independent

How can you use “ubiquitin-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

The well-known ubiquitin-dependent pathway involves the covalent attachment of ubiquitin to substrate proteins to form polyubiquitin chain, which then targets the marked substrates to proteasome for degradation [ 17 19 20 ] . The ubiquitin-independent pathway is not well defined, but involves targeting proteins other than ubiquitin.
The best-characterized example of ubiquitin-independent degradation is the degradation of ornithine decarboxylase (ODC), which is dependent upon ODC interaction with the targeting protein antizyme (Az) [ 18 ] . How ubiquitinated substrates or Az-bound ODC is recognized by the 26S proteasome is not well understood.
The 20S proteasome then combines with two 19S regulatory complex to form the 26S proteasome, which is the degradation machinery responsible for both ubiquitin-dependent and ubiquitin-independent degradation [ 37 ] . The prosequences of the proteolytic β subunits are important to keep the proteolytic sites inaccessible to the substrates.
This could be a common mechanism for ubiquitin-independent degradation pathways.