Example sentences for: tyrosine-phosphorylation

How can you use “tyrosine-phosphorylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The JAK/STAT signaling pathway is involved in many cytokines, hormones, and growth factors mediated signaling pathways to regulate a variety of biological responses, including development, cell differentiation, proliferation and survival [ 7 8 ] . Once STAT proteins are activated by tyrosine-phosphorylation, form homo or heterodimers that are translocated to the nucleus, where they can bind to specific sequences in the DNA, thereby stimulating gene transcription.

  • Despite numerous reported differences, it does appear that diverse GPCRs share common mechanistic themes during ERK stimulation, including the tyrosine-phosphorylation of Shc and its complexing with Grb2, mSOS recruitment, the GTP-loading of Ras, and Raf-1 activation leading to MEK-1 phosphorylation [ 1 ] . However, the progression of each of these downstream events after GPCR stimulation depends first on the tyrosine phosphorylation of a membrane-bound protein that will be used as a scaffold, which will bind the other proteins (e.g.

  • This is based on aggregation assays showing different time courses, additive dose response relationships, and differential co-localization of the dystrophin complex, and on biochemical observations indicating the lack of requirement for MuSK, and the lack of tyrosine-phosphorylation of receptors during LN1 but not agrin induced aggregation [ 1 2 4 ] . The very minimal receptor aggregation seen in agrin deficient mice certainly argues that laminins are not sufficient to trigger receptor aggregation [ 5 ] . More recently we have shown that agrin and LN1 induced aggregates can also be differentiated on the basis of the ultrastructural arrangement of receptors within aggregates [ 6 ] .


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