Words similar to tyrosines
Example sentences for: tyrosines
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We can also use this approach to ask which tyrosines within the SD of Cas can act as decoys for specific downstream signals attributed to the SD of Cas.
The mutation of one of the tyrosines (Y318F) in the δ-OR or the presence of the Src inhibitor, PP1, significantly reduces tyrosine phosphorylation of this receptor and its ability to activate ERKs [ 11 13 ] . However, a small degree of δ-OR agonist-mediated ERK activation remained in cells expressing the Y318F mutant receptor, suggesting that a second mechanism or an additional tyrosine could be involved.
Cas is a protein which migrates with an apparent mass of approximately 130 kDa, with a N-terminal SH3 domain, a central substrate domain (SD) with up to 15 tyrosines which can be phosphorylated, a C-terminal region with a proline-rich region, and two tyrosine phosphorylation sites capable of binding Src kinases (Src binding domain (SBD)) [ 6 18 ] . The latter SBD domain regulates the ability of Src to activate the serum response element, as well as in the phosphorylation of the SD of Cas by Src [ 18 19 20 ] . The substrate domain controls adhesion and migration and the majority of the tyrosines within this domain are of the sequence YQXP (5) or YDXP (10), which when phosphorylated, bind to the adaptors c-crk, nck and AND-34 [ 16 21 22 23 ] . The importance of these molecules in Cas function is unclear, however c-crk seems to be critical in the regulation of adhesion and migration mediated by Cas.
The corresponding control peptide with tyrosines instead of sulfotyrosines, and N36 (SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVL) and C34 (WIEWDREINNYTSIIYSLIEESQNQQEKNEQELL) peptide constituents of the gp41 core [ 20 21 ] of HIV-1 BaL were from AnaSpec, Inc., San Jose, CA.
Second, molecules with the Y130E mutations did not co-immunoprecipitate with the BCR [ 58 ] . A second example involves an in vitro model of histamine release in the Syk-deficient RBL-2H3 cell line [ 59 ] . When tyrosines 519 and 520 were mutated and introduced into Syk-deficient RBL-2H3 cells, these Syk molecules were capable of phosphorylation of c3b substrate in an ICKA.
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