Words similar to tyrosines
Example sentences for: tyrosines
How can you use “tyrosines” in a sentence? Here are some example sentences to help you improve your vocabulary:
The adaptor protein Cas has a N-terminal SH3 domain, a large number of tyrosines that serve as potential kinase substrates within its substrate domain and a C-terminal Src binding domain (Fig.
This second class of adaptor proteins is characterized by a substrate domain with multiple tyrosines for phosphorylation by upstream kinases.
Although these distinctive features suggest that Rlk may have atypical functions, Rlk shares with Btk kinases the homologous proline-rich motif that binds the SH3 domains of Src kinases and the tyrosines at equivalent sites in the SH3 and kinase domains.
Second, molecules with the Y130E mutations did not co-immunoprecipitate with the BCR [ 58 ] . A second example involves an in vitro model of histamine release in the Syk-deficient RBL-2H3 cell line [ 59 ] . When tyrosines 519 and 520 were mutated and introduced into Syk-deficient RBL-2H3 cells, these Syk molecules were capable of phosphorylation of c3b substrate in an ICKA.
Cas is a protein which migrates with an apparent mass of approximately 130 kDa, with a N-terminal SH3 domain, a central substrate domain (SD) with up to 15 tyrosines which can be phosphorylated, a C-terminal region with a proline-rich region, and two tyrosine phosphorylation sites capable of binding Src kinases (Src binding domain (SBD)) [ 6 18 ] . The latter SBD domain regulates the ability of Src to activate the serum response element, as well as in the phosphorylation of the SD of Cas by Src [ 18 19 20 ] . The substrate domain controls adhesion and migration and the majority of the tyrosines within this domain are of the sequence YQXP (5) or YDXP (10), which when phosphorylated, bind to the adaptors c-crk, nck and AND-34 [ 16 21 22 23 ] . The importance of these molecules in Cas function is unclear, however c-crk seems to be critical in the regulation of adhesion and migration mediated by Cas.
Loading...