Words similar to tyrosinase
Example sentences for: tyrosinase
How can you use “tyrosinase” in a sentence? Here are some example sentences to help you improve your vocabulary:
Tyrosinase alone or any other immunomarker used individually, would be less sensitive than a cocktail.
The cocktail was not compared with S-100 in this study, as its role in evaluation of sentinel lymph nodes of melanoma was already demonstrated to be unreliable even in comparison to MART-1 and Melan-A individually in the previous study [ 6 ] . We did not compare tyrosinase alone with the cocktail because the questionable contribution of such a study would not be offset by the additional cost involved.
In the present study, we evaluated the combination of monoclonal antibodies; MART-1, Melan-A, and Tyrosinase in optimized titers (Table 1) for evaluation of sentinel lymph nodes of cutaneous melanoma.
Previously, we had demonstrated higher diagnostic accuracy in detecting and diagnosing melanoma micrometastases in sentinel lymph node using monoclonal antibodies to MART-1 (clone M2-7C10) and Melan-A (clone A103) in comparison to the traditionally used immunohistochemical markers, S-100 protein (S-100) and HMB-45 [ 6 ] . The cytoplasmic staining with these immunomarkers does not obscure the nuclear details and facilitates accurate interpretation of tumor cells, macrophages, and nevus cells in contrast to S-100 [ 6 12 ] . A monoclonal antibody to a third melanoma immunomarker, Tyrosinase (clone T311), showed an immunostaining pattern similar to MART-1 and Melan-A [ 13 ] .
As previously reported, MART-1 and Melan-A demonstrated predominantly cytoplasmic staining of melanoma cells [ 6 ] . The monoclonal antibody (T311) to tyrosinase, has been reported to demonstrate high sensitivity and specificity for melanoma [ 13 ] . It has also demonstrated an immunostaining pattern in sentinel lymph nodes identical to MART-1 and Melan-A.
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